Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model

Murine leukemia virus (MLV) integrase (IN) lacking the C-terminal tail peptide (TP) loses its interaction with the host bromodomain and extraterminal (BET) proteins and displays decreased integration at promoter/enhancers and transcriptional start sites/CpG islands. MLV lacking the IN TP via an alte...

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Detalles Bibliográficos
Autores principales: Loyola, Lorenz, Achuthan, Vasudevan, Gilroy, Kathryn, Borland, Gillian, Kilbey, Anna, Mackay, Nancy, Bell, Margaret, Hay, Jodie, Aiyer, Sriram, Fingerman, Dylan, Villanueva, Rodrigo A., Cameron, Ewan, Kozak, Christine A., Engelman, Alan N., Neil, James, Roth, Monica J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974304/
https://www.ncbi.nlm.nih.gov/pubmed/31815961
http://dx.doi.org/10.1371/journal.ppat.1008154

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