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Detecting Early Pancreatic Cancer: Current Problems and Future Prospects

The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. For this reason, early detection is essenti...

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Autores principales: Matsubayashi, Hiroyuki, Ishiwatari, Hirotoshi, Sasaki, Keiko, Uesaka, Katsuhiko, Ono, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974337/
https://www.ncbi.nlm.nih.gov/pubmed/31009958
http://dx.doi.org/10.5009/gnl18491
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author Matsubayashi, Hiroyuki
Ishiwatari, Hirotoshi
Sasaki, Keiko
Uesaka, Katsuhiko
Ono, Hiroyuki
author_facet Matsubayashi, Hiroyuki
Ishiwatari, Hirotoshi
Sasaki, Keiko
Uesaka, Katsuhiko
Ono, Hiroyuki
author_sort Matsubayashi, Hiroyuki
collection PubMed
description The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. For this reason, early detection is essential, but most patients with early-stage PC are asymptomatic. Early detection of PC has been reported to require screening of high-risk individuals (HRIs), such as those with a family history of PC, inherited cancer syndromes, intraductal papillary mucinous neoplasm, or chronic pancreatitis. Studies on screening of these HRIs have confirmed a significantly better prognosis among patients with PC who were screened than for patients with PC who were not screened. However, to date in Japan, most patients with early-stage PC diagnosed in routine clinics were not diagnosed during annual health checks or by surveillance; rather, PC was detected in these patients by incidental findings during examinations for other diseases. We need to increase the precision of the PC screening and diagnostic processes by introducing new technologies, and we need to pay greater attention to incidental clinical findings.
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spelling pubmed-69743372020-02-03 Detecting Early Pancreatic Cancer: Current Problems and Future Prospects Matsubayashi, Hiroyuki Ishiwatari, Hirotoshi Sasaki, Keiko Uesaka, Katsuhiko Ono, Hiroyuki Gut Liver Review The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. For this reason, early detection is essential, but most patients with early-stage PC are asymptomatic. Early detection of PC has been reported to require screening of high-risk individuals (HRIs), such as those with a family history of PC, inherited cancer syndromes, intraductal papillary mucinous neoplasm, or chronic pancreatitis. Studies on screening of these HRIs have confirmed a significantly better prognosis among patients with PC who were screened than for patients with PC who were not screened. However, to date in Japan, most patients with early-stage PC diagnosed in routine clinics were not diagnosed during annual health checks or by surveillance; rather, PC was detected in these patients by incidental findings during examinations for other diseases. We need to increase the precision of the PC screening and diagnostic processes by introducing new technologies, and we need to pay greater attention to incidental clinical findings. Editorial Office of Gut and Liver 2020-01 2019-04-23 /pmc/articles/PMC6974337/ /pubmed/31009958 http://dx.doi.org/10.5009/gnl18491 Text en Copyright © 2020 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Matsubayashi, Hiroyuki
Ishiwatari, Hirotoshi
Sasaki, Keiko
Uesaka, Katsuhiko
Ono, Hiroyuki
Detecting Early Pancreatic Cancer: Current Problems and Future Prospects
title Detecting Early Pancreatic Cancer: Current Problems and Future Prospects
title_full Detecting Early Pancreatic Cancer: Current Problems and Future Prospects
title_fullStr Detecting Early Pancreatic Cancer: Current Problems and Future Prospects
title_full_unstemmed Detecting Early Pancreatic Cancer: Current Problems and Future Prospects
title_short Detecting Early Pancreatic Cancer: Current Problems and Future Prospects
title_sort detecting early pancreatic cancer: current problems and future prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974337/
https://www.ncbi.nlm.nih.gov/pubmed/31009958
http://dx.doi.org/10.5009/gnl18491
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