Cargando…

Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC

Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality. Host-derived immunological factors that affect HNSCC tumor development and metastasis are not completely understood. We investigated the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Kelvin, Ryan, Nathan, Volpedo, Greta, Varikuti, Sanjay, Satoskar, Abhay R., Oghumu, Steve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974475/ https://www.ncbi.nlm.nih.gov/pubmed/32010142 http://dx.doi.org/10.3389/fimmu.2019.03095

Ejemplares similares

The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications
por: Ryan, Nathan, et al.
Publicado: (2020)

STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade
por: Varikuti, Sanjay, et al.
Publicado: (2017)

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases
por: Volpedo, Greta, et al.
Publicado: (2019)

Multilocus microsatellite signature and identification of specific molecular markers for Leishmania aethiopica
por: Kebede, Nigatu, et al.
Publicado: (2013)

A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells
por: Natarajan, Gayathri, et al.
Publicado: (2016)

Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites
por: Varikuti, Sanjay, et al.
Publicado: (2018)

Ibrutinib treatment inhibits breast cancer progression and metastasis by inducing conversion of myeloid-derived suppressor cells to dendritic cells
por: Varikuti, Sanjay, et al.
Publicado: (2020)

Black Raspberries and Protocatechuic Acid Mitigate DNFB-Induced Contact Hypersensitivity by Down-Regulating Dendritic Cell Activation and Inhibiting Mediators of Effector Responses
por: Anderson, Kelvin, et al.
Publicado: (2020)

Leishmania donovani Infection Induces Anemia in Hamsters by Differentially Altering Erythropoiesis in Bone Marrow and Spleen
por: Lafuse, William P., et al.
Publicado: (2013)

STAT1 is regulated by TRIM24 and promotes immunosuppression in head and neck squamous carcinoma cells, but enhances T cell antitumour immunity in the tumour microenvironment
por: Anderson, Kelvin, et al.
Publicado: (2022)

Ly6C(hi) inflammatory monocytes promote susceptibility to Leishmania donovani infection
por: Terrazas, Cesar, et al.
Publicado: (2017)

The emerging role of dendritic cells in the host immune response against Helicobacter pylori
por: Oghumu, Steve, et al.
Publicado: (2014)

Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development
por: Volpedo, Greta, et al.
Publicado: (2021)

PI3K-γ inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens
por: Oghumu, Steve, et al.
Publicado: (2013)

Deficiency of p110δ Isoform of the Phosphoinositide 3 Kinase Leads to Enhanced Resistance to Leishmania donovani
por: Khadem, Forough, et al.
Publicado: (2014)

Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis
por: Volpedo, Greta, et al.
Publicado: (2022)

Mechanisms of Immunopathogenesis in Cutaneous Leishmaniasis And Post Kala-azar Dermal Leishmaniasis (PKDL)
por: Volpedo, Greta, et al.
Publicado: (2021)

Tumor growth suppression by inhibiting both autophagy and STAT3 signaling in HNSCC
por: Fan, Teng-Fei, et al.
Publicado: (2015)

Inhibition of PI3K Isoform p110γ Increases Both Anti-Tumor and Immunosuppressive Responses to Aggressive Murine Head and Neck Squamous Cell Carcinoma with Low Immunogenicity
por: Anderson, Kelvin, et al.
Publicado: (2021)

Revival of Leishmanization and Leishmanin
por: Pacheco-Fernandez, Thalia, et al.
Publicado: (2021)

The History of Live Attenuated Centrin Gene-Deleted Leishmania Vaccine Candidates
por: Volpedo, Greta, et al.
Publicado: (2022)

Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention
por: Ryan, Nathan M., et al.
Publicado: (2022)

Cytokines and Their STATs in Cutaneous and Visceral Leishmaniasis
por: Cummings, Hannah E., et al.
Publicado: (2010)

CXCR3-Dependent CD4(+) T Cells Are Required to Activate Inflammatory Monocytes for Defense against Intestinal Infection
por: Cohen, Sara B., et al.
Publicado: (2013)

Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner
por: Musa, Md. Abu, et al.
Publicado: (2019)

Profound and selective lymphopaenia in primary lymphatic anomaly patients demonstrates the significance of lymphatic-lymphocyte interactions
por: Pearce, Julian, et al.
Publicado: (2023)

Bioflavonoid-Induced Apoptosis and DNA Damage in Amastigotes and Promastigotes of Leishmania donovani: Deciphering the Mode of Action
por: Mehwish, Shaila, et al.
Publicado: (2021)

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis
por: Karmakar, Subir, et al.
Publicado: (2022)

Leishmania major centrin knock-out parasites reprogram tryptophan metabolism to induce a pro-inflammatory response
por: Oljuskin, Timur, et al.
Publicado: (2023)

Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer
por: Charan, Manish, et al.
Publicado: (2020)

How to Increase the Efficacy of Immunotherapy in NSCLC and HNSCC: Role of Radiation Therapy, Chemotherapy, and Other Strategies
por: Nardone, Valerio, et al.
Publicado: (2018)

Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC
por: Chi, Hao, et al.
Publicado: (2022)

Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity
por: Chi, Hao, et al.
Publicado: (2023)

Leishmania mexicana centrin knockout parasites promote M1-polarizing metabolic changes
por: Volpedo, Greta, et al.
Publicado: (2023)

Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response
por: Ryan, Nathan M., et al.
Publicado: (2019)

Deciphering the role of HPV-mediated metabolic regulation in shaping the tumor microenvironment and its implications for immunotherapy in HNSCC
por: Gong, Xiangjin, et al.
Publicado: (2023)

Fibroblast-Derived CXCL12 Promotes Breast Cancer Metastasis by Facilitating Tumor Cell Intravasation
por: Ahirwar, Dinesh K., et al.
Publicado: (2018)

Inflammation and Lymphatic Function
por: Schwager, Simon, et al.
Publicado: (2019)

EVI1 as a Marker for Lymph Node Metastasis in HNSCC
por: Idel, Christian, et al.
Publicado: (2020)

ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
por: Ayoub, C, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_n9pkqptquptrqetnq3im45i1o5