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Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase

As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against Staphylococcus aureus. In this paper, we demonstrat...

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Detalles Bibliográficos
Autores principales:	Dong, Chuanjiang, Zhou, Jingxuan, Wang, Peng, Li, Tao, Zhao, Ying, Ren, Xiaoyuan, Lu, Jun, Wang, Jun, Holmgren, Arne, Zou, Lili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974526/ https://www.ncbi.nlm.nih.gov/pubmed/32010088 http://dx.doi.org/10.3389/fmicb.2019.03016

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