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Functional microbiome deficits associated with ageing: Chronological age threshold

Composition of the gut microbiota changes during ageing, but questions remain about whether age is also associated with deficits in microbiome function and whether these changes occur sharply or progressively. The ability to define these deficits in populations of different ages may help determine a...

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Autores principales: Ruiz‐Ruiz, Susana, Sanchez‐Carrillo, Sergio, Ciordia, Sergio, Mena, María C., Méndez‐García, Celia, Rojo, David, Bargiela, Rafael, Zubeldia‐Varela, Elisa, Martínez‐Martínez, Mónica, Barbas, Coral, Ferrer, Manuel, Moya, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974723/
https://www.ncbi.nlm.nih.gov/pubmed/31730262
http://dx.doi.org/10.1111/acel.13063
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author Ruiz‐Ruiz, Susana
Sanchez‐Carrillo, Sergio
Ciordia, Sergio
Mena, María C.
Méndez‐García, Celia
Rojo, David
Bargiela, Rafael
Zubeldia‐Varela, Elisa
Martínez‐Martínez, Mónica
Barbas, Coral
Ferrer, Manuel
Moya, Andrés
author_facet Ruiz‐Ruiz, Susana
Sanchez‐Carrillo, Sergio
Ciordia, Sergio
Mena, María C.
Méndez‐García, Celia
Rojo, David
Bargiela, Rafael
Zubeldia‐Varela, Elisa
Martínez‐Martínez, Mónica
Barbas, Coral
Ferrer, Manuel
Moya, Andrés
author_sort Ruiz‐Ruiz, Susana
collection PubMed
description Composition of the gut microbiota changes during ageing, but questions remain about whether age is also associated with deficits in microbiome function and whether these changes occur sharply or progressively. The ability to define these deficits in populations of different ages may help determine a chronological age threshold at which deficits occur and subsequently identify innovative dietary strategies for active and healthy ageing. Here, active gut microbiota and associated metabolic functions were evaluated using shotgun proteomics in three well‐defined age groups consisting of 30 healthy volunteers, namely, ten infants, ten adults and ten elderly individuals. Samples from each volunteer at intervals of up to 6 months (n = 83 samples) were used for validation. Ageing gradually increases the diversity of gut bacteria that actively synthesize proteins, that is by 1.4‐fold from infants to elderly individuals. An analysis of functional deficits consistently identifies a relationship between tryptophan and indole metabolism and ageing (p < 2.8e(−8)). Indeed, the synthesis of proteins involved in tryptophan and indole production and the faecal concentrations of these metabolites are directly correlated (r (2) > .987) and progressively decrease with age (r (2) > .948). An age threshold for a 50% decrease is observed ca. 11–31 years old, and a greater than 90% reduction is observed from the ages of 34–54 years. Based on recent investigations linking tryptophan with abundance of indole and other “healthy” longevity molecules and on the results from this small cohort study, dietary interventions aimed at manipulating tryptophan deficits since a relatively “young” age of 34 and, particularly, in the elderly are recommended.
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spelling pubmed-69747232020-01-28 Functional microbiome deficits associated with ageing: Chronological age threshold Ruiz‐Ruiz, Susana Sanchez‐Carrillo, Sergio Ciordia, Sergio Mena, María C. Méndez‐García, Celia Rojo, David Bargiela, Rafael Zubeldia‐Varela, Elisa Martínez‐Martínez, Mónica Barbas, Coral Ferrer, Manuel Moya, Andrés Aging Cell Original Articles Composition of the gut microbiota changes during ageing, but questions remain about whether age is also associated with deficits in microbiome function and whether these changes occur sharply or progressively. The ability to define these deficits in populations of different ages may help determine a chronological age threshold at which deficits occur and subsequently identify innovative dietary strategies for active and healthy ageing. Here, active gut microbiota and associated metabolic functions were evaluated using shotgun proteomics in three well‐defined age groups consisting of 30 healthy volunteers, namely, ten infants, ten adults and ten elderly individuals. Samples from each volunteer at intervals of up to 6 months (n = 83 samples) were used for validation. Ageing gradually increases the diversity of gut bacteria that actively synthesize proteins, that is by 1.4‐fold from infants to elderly individuals. An analysis of functional deficits consistently identifies a relationship between tryptophan and indole metabolism and ageing (p < 2.8e(−8)). Indeed, the synthesis of proteins involved in tryptophan and indole production and the faecal concentrations of these metabolites are directly correlated (r (2) > .987) and progressively decrease with age (r (2) > .948). An age threshold for a 50% decrease is observed ca. 11–31 years old, and a greater than 90% reduction is observed from the ages of 34–54 years. Based on recent investigations linking tryptophan with abundance of indole and other “healthy” longevity molecules and on the results from this small cohort study, dietary interventions aimed at manipulating tryptophan deficits since a relatively “young” age of 34 and, particularly, in the elderly are recommended. John Wiley and Sons Inc. 2019-11-15 2020-01 /pmc/articles/PMC6974723/ /pubmed/31730262 http://dx.doi.org/10.1111/acel.13063 Text en © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ruiz‐Ruiz, Susana
Sanchez‐Carrillo, Sergio
Ciordia, Sergio
Mena, María C.
Méndez‐García, Celia
Rojo, David
Bargiela, Rafael
Zubeldia‐Varela, Elisa
Martínez‐Martínez, Mónica
Barbas, Coral
Ferrer, Manuel
Moya, Andrés
Functional microbiome deficits associated with ageing: Chronological age threshold
title Functional microbiome deficits associated with ageing: Chronological age threshold
title_full Functional microbiome deficits associated with ageing: Chronological age threshold
title_fullStr Functional microbiome deficits associated with ageing: Chronological age threshold
title_full_unstemmed Functional microbiome deficits associated with ageing: Chronological age threshold
title_short Functional microbiome deficits associated with ageing: Chronological age threshold
title_sort functional microbiome deficits associated with ageing: chronological age threshold
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974723/
https://www.ncbi.nlm.nih.gov/pubmed/31730262
http://dx.doi.org/10.1111/acel.13063
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