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(Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System
Na(+)/H(+) exchangers (NHEs) are expressed in virtually all human tissues and organs. Two major tasks of those NHE isoforms that are located in plasma membranes are cell volume control by Na(+)-uptake and cellular pH regulation by H(+)-extrusion. Several NHEs, particularly NHE 1–4 and 8, are involve...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974801/ https://www.ncbi.nlm.nih.gov/pubmed/32009977 http://dx.doi.org/10.3389/fphys.2019.01566 |
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author | Cao, Li Yuan, Zhenglin Liu, Mei Stock, Christian |
author_facet | Cao, Li Yuan, Zhenglin Liu, Mei Stock, Christian |
author_sort | Cao, Li |
collection | PubMed |
description | Na(+)/H(+) exchangers (NHEs) are expressed in virtually all human tissues and organs. Two major tasks of those NHE isoforms that are located in plasma membranes are cell volume control by Na(+)-uptake and cellular pH regulation by H(+)-extrusion. Several NHEs, particularly NHE 1–4 and 8, are involved in the pathogenesis of diseases of the digestive system such as inflammatory bowel disease (ulcerative colitis, Crohn’s disease) and gastric and colorectal tumorigenesis. In the present review, we describe the physiological purposes, possible malfunctions and pathophysiological effects of the different NHE isoforms along the alimentary canal from esophagus to colon, including pancreas, liver and gallbladder. Particular attention is paid to the functions of NHEs in injury repair and to the role of NHE1 in Barrett’s esophagus. The impact of NHEs on gut microbiota and intestinal mucosal integrity is also dealt with. As the hitherto existing findings are not always consistent, sometimes even controversial, they are compared and critically discussed. |
format | Online Article Text |
id | pubmed-6974801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69748012020-01-31 (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System Cao, Li Yuan, Zhenglin Liu, Mei Stock, Christian Front Physiol Physiology Na(+)/H(+) exchangers (NHEs) are expressed in virtually all human tissues and organs. Two major tasks of those NHE isoforms that are located in plasma membranes are cell volume control by Na(+)-uptake and cellular pH regulation by H(+)-extrusion. Several NHEs, particularly NHE 1–4 and 8, are involved in the pathogenesis of diseases of the digestive system such as inflammatory bowel disease (ulcerative colitis, Crohn’s disease) and gastric and colorectal tumorigenesis. In the present review, we describe the physiological purposes, possible malfunctions and pathophysiological effects of the different NHE isoforms along the alimentary canal from esophagus to colon, including pancreas, liver and gallbladder. Particular attention is paid to the functions of NHEs in injury repair and to the role of NHE1 in Barrett’s esophagus. The impact of NHEs on gut microbiota and intestinal mucosal integrity is also dealt with. As the hitherto existing findings are not always consistent, sometimes even controversial, they are compared and critically discussed. Frontiers Media S.A. 2020-01-15 /pmc/articles/PMC6974801/ /pubmed/32009977 http://dx.doi.org/10.3389/fphys.2019.01566 Text en Copyright © 2020 Cao, Yuan, Liu and Stock. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Cao, Li Yuan, Zhenglin Liu, Mei Stock, Christian (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System |
title | (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System |
title_full | (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System |
title_fullStr | (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System |
title_full_unstemmed | (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System |
title_short | (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System |
title_sort | (patho-)physiology of na(+)/h(+) exchangers (nhes) in the digestive system |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974801/ https://www.ncbi.nlm.nih.gov/pubmed/32009977 http://dx.doi.org/10.3389/fphys.2019.01566 |
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