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(Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System

Na(+)/H(+) exchangers (NHEs) are expressed in virtually all human tissues and organs. Two major tasks of those NHE isoforms that are located in plasma membranes are cell volume control by Na(+)-uptake and cellular pH regulation by H(+)-extrusion. Several NHEs, particularly NHE 1–4 and 8, are involve...

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Autores principales: Cao, Li, Yuan, Zhenglin, Liu, Mei, Stock, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974801/
https://www.ncbi.nlm.nih.gov/pubmed/32009977
http://dx.doi.org/10.3389/fphys.2019.01566
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author Cao, Li
Yuan, Zhenglin
Liu, Mei
Stock, Christian
author_facet Cao, Li
Yuan, Zhenglin
Liu, Mei
Stock, Christian
author_sort Cao, Li
collection PubMed
description Na(+)/H(+) exchangers (NHEs) are expressed in virtually all human tissues and organs. Two major tasks of those NHE isoforms that are located in plasma membranes are cell volume control by Na(+)-uptake and cellular pH regulation by H(+)-extrusion. Several NHEs, particularly NHE 1–4 and 8, are involved in the pathogenesis of diseases of the digestive system such as inflammatory bowel disease (ulcerative colitis, Crohn’s disease) and gastric and colorectal tumorigenesis. In the present review, we describe the physiological purposes, possible malfunctions and pathophysiological effects of the different NHE isoforms along the alimentary canal from esophagus to colon, including pancreas, liver and gallbladder. Particular attention is paid to the functions of NHEs in injury repair and to the role of NHE1 in Barrett’s esophagus. The impact of NHEs on gut microbiota and intestinal mucosal integrity is also dealt with. As the hitherto existing findings are not always consistent, sometimes even controversial, they are compared and critically discussed.
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spelling pubmed-69748012020-01-31 (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System Cao, Li Yuan, Zhenglin Liu, Mei Stock, Christian Front Physiol Physiology Na(+)/H(+) exchangers (NHEs) are expressed in virtually all human tissues and organs. Two major tasks of those NHE isoforms that are located in plasma membranes are cell volume control by Na(+)-uptake and cellular pH regulation by H(+)-extrusion. Several NHEs, particularly NHE 1–4 and 8, are involved in the pathogenesis of diseases of the digestive system such as inflammatory bowel disease (ulcerative colitis, Crohn’s disease) and gastric and colorectal tumorigenesis. In the present review, we describe the physiological purposes, possible malfunctions and pathophysiological effects of the different NHE isoforms along the alimentary canal from esophagus to colon, including pancreas, liver and gallbladder. Particular attention is paid to the functions of NHEs in injury repair and to the role of NHE1 in Barrett’s esophagus. The impact of NHEs on gut microbiota and intestinal mucosal integrity is also dealt with. As the hitherto existing findings are not always consistent, sometimes even controversial, they are compared and critically discussed. Frontiers Media S.A. 2020-01-15 /pmc/articles/PMC6974801/ /pubmed/32009977 http://dx.doi.org/10.3389/fphys.2019.01566 Text en Copyright © 2020 Cao, Yuan, Liu and Stock. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Cao, Li
Yuan, Zhenglin
Liu, Mei
Stock, Christian
(Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System
title (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System
title_full (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System
title_fullStr (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System
title_full_unstemmed (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System
title_short (Patho-)Physiology of Na(+)/H(+) Exchangers (NHEs) in the Digestive System
title_sort (patho-)physiology of na(+)/h(+) exchangers (nhes) in the digestive system
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974801/
https://www.ncbi.nlm.nih.gov/pubmed/32009977
http://dx.doi.org/10.3389/fphys.2019.01566
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