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The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis
Psychotic disorders are characterized by theory of mind (ToM) impairment. Although ToM undergoes maturational changes throughout adolescence, there is a lack of studies examining ToM performance and its brain functional correlates in individuals with an early onset of psychosis (EOP; onset prior to...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974903/ https://www.ncbi.nlm.nih.gov/pubmed/31791005 http://dx.doi.org/10.1016/j.dcn.2019.100726 |
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author | Ilzarbe, Daniel de la Serna, Elena Baeza, Inmaculada Rosa, Mireia Puig, Olga Calvo, Anna Masias, Mireia Borras, Roger Pariente, Jose C. Castro-Fornieles, Josefina Sugranyes, Gisela |
author_facet | Ilzarbe, Daniel de la Serna, Elena Baeza, Inmaculada Rosa, Mireia Puig, Olga Calvo, Anna Masias, Mireia Borras, Roger Pariente, Jose C. Castro-Fornieles, Josefina Sugranyes, Gisela |
author_sort | Ilzarbe, Daniel |
collection | PubMed |
description | Psychotic disorders are characterized by theory of mind (ToM) impairment. Although ToM undergoes maturational changes throughout adolescence, there is a lack of studies examining ToM performance and its brain functional correlates in individuals with an early onset of psychosis (EOP; onset prior to age 18), and its relationship with age. Twenty-seven individuals with EOP were compared with 41 healthy volunteers using the “Reading-the-Mind-in-the-Eyes” Test, as a measure of ToM performance. A resting-state functional MRI scan was also acquired, in which the default mode network was used to identify areas relevant to ToM processing employing independent component analysis. Group effects revealed worse ToM performance and less intrinsic functional connectivity in the medial prefrontal cortex in EOP relative to healthy volunteers. Group by age interaction revealed age-positive associations in ToM task performance and in intrinsic connectivity in the medial prefrontal cortex in healthy volunteers, which were not present in EOP. Differences in ToM performance were partially mediated by intrinsic functional connectivity in the medial prefrontal cortex. Poorer ToM performance in EOP, coupled with less medial prefrontal cortex connectivity, could be associated with the impact of psychosis during a critical period of development of the social brain, limiting normative age-related maturation. |
format | Online Article Text |
id | pubmed-6974903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69749032020-01-27 The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis Ilzarbe, Daniel de la Serna, Elena Baeza, Inmaculada Rosa, Mireia Puig, Olga Calvo, Anna Masias, Mireia Borras, Roger Pariente, Jose C. Castro-Fornieles, Josefina Sugranyes, Gisela Dev Cogn Neurosci Original Research Psychotic disorders are characterized by theory of mind (ToM) impairment. Although ToM undergoes maturational changes throughout adolescence, there is a lack of studies examining ToM performance and its brain functional correlates in individuals with an early onset of psychosis (EOP; onset prior to age 18), and its relationship with age. Twenty-seven individuals with EOP were compared with 41 healthy volunteers using the “Reading-the-Mind-in-the-Eyes” Test, as a measure of ToM performance. A resting-state functional MRI scan was also acquired, in which the default mode network was used to identify areas relevant to ToM processing employing independent component analysis. Group effects revealed worse ToM performance and less intrinsic functional connectivity in the medial prefrontal cortex in EOP relative to healthy volunteers. Group by age interaction revealed age-positive associations in ToM task performance and in intrinsic connectivity in the medial prefrontal cortex in healthy volunteers, which were not present in EOP. Differences in ToM performance were partially mediated by intrinsic functional connectivity in the medial prefrontal cortex. Poorer ToM performance in EOP, coupled with less medial prefrontal cortex connectivity, could be associated with the impact of psychosis during a critical period of development of the social brain, limiting normative age-related maturation. Elsevier 2019-11-05 /pmc/articles/PMC6974903/ /pubmed/31791005 http://dx.doi.org/10.1016/j.dcn.2019.100726 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Ilzarbe, Daniel de la Serna, Elena Baeza, Inmaculada Rosa, Mireia Puig, Olga Calvo, Anna Masias, Mireia Borras, Roger Pariente, Jose C. Castro-Fornieles, Josefina Sugranyes, Gisela The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis |
title | The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis |
title_full | The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis |
title_fullStr | The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis |
title_full_unstemmed | The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis |
title_short | The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis |
title_sort | relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974903/ https://www.ncbi.nlm.nih.gov/pubmed/31791005 http://dx.doi.org/10.1016/j.dcn.2019.100726 |
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