Altered neural correlates of episodic memory in adolescents with severe obesity
Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their asso...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974906/ https://www.ncbi.nlm.nih.gov/pubmed/31839215 http://dx.doi.org/10.1016/j.dcn.2019.100727 |
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author | Pearce, Alaina L Mackey, Eleanor Cherry, J. Bradley C. Olson, Alexandra You, Xiaozhen Nadler, Evan P Vaidya, Chandan J |
author_facet | Pearce, Alaina L Mackey, Eleanor Cherry, J. Bradley C. Olson, Alexandra You, Xiaozhen Nadler, Evan P Vaidya, Chandan J |
author_sort | Pearce, Alaina L |
collection | PubMed |
description | Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their associated context in adolescents with severe obesity (age 14–18 years, 43% male). Despite similar subsequent memory as adolescents without obesity (BMI for age and sex <95th percentile), those with severe obesity (BMI for age and sex 120% above the 95th percentile) showed reduced hippocampal, parahippocampal, frontal, and parietal engagement during encoding of remembered visual scenes and greater lateral temporal engagement during encoding of their associated context. Standardized testing revealed a trend level group difference in memory performance, with a larger magnitude of obesity-related difference in recollection-related memory that was mediated by individual differences in lateral temporal activation during contextual encoding. The observed widespread functional alterations are concerning in light of the importance of mnemonic processing for academic achievement and feeding behavior and underscore the need for prevention and intervention initiatives for pediatric obesity. |
format | Online Article Text |
id | pubmed-6974906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69749062020-01-27 Altered neural correlates of episodic memory in adolescents with severe obesity Pearce, Alaina L Mackey, Eleanor Cherry, J. Bradley C. Olson, Alexandra You, Xiaozhen Nadler, Evan P Vaidya, Chandan J Dev Cogn Neurosci Original Research Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their associated context in adolescents with severe obesity (age 14–18 years, 43% male). Despite similar subsequent memory as adolescents without obesity (BMI for age and sex <95th percentile), those with severe obesity (BMI for age and sex 120% above the 95th percentile) showed reduced hippocampal, parahippocampal, frontal, and parietal engagement during encoding of remembered visual scenes and greater lateral temporal engagement during encoding of their associated context. Standardized testing revealed a trend level group difference in memory performance, with a larger magnitude of obesity-related difference in recollection-related memory that was mediated by individual differences in lateral temporal activation during contextual encoding. The observed widespread functional alterations are concerning in light of the importance of mnemonic processing for academic achievement and feeding behavior and underscore the need for prevention and intervention initiatives for pediatric obesity. Elsevier 2019-11-06 /pmc/articles/PMC6974906/ /pubmed/31839215 http://dx.doi.org/10.1016/j.dcn.2019.100727 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Pearce, Alaina L Mackey, Eleanor Cherry, J. Bradley C. Olson, Alexandra You, Xiaozhen Nadler, Evan P Vaidya, Chandan J Altered neural correlates of episodic memory in adolescents with severe obesity |
title | Altered neural correlates of episodic memory in adolescents with severe obesity |
title_full | Altered neural correlates of episodic memory in adolescents with severe obesity |
title_fullStr | Altered neural correlates of episodic memory in adolescents with severe obesity |
title_full_unstemmed | Altered neural correlates of episodic memory in adolescents with severe obesity |
title_short | Altered neural correlates of episodic memory in adolescents with severe obesity |
title_sort | altered neural correlates of episodic memory in adolescents with severe obesity |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974906/ https://www.ncbi.nlm.nih.gov/pubmed/31839215 http://dx.doi.org/10.1016/j.dcn.2019.100727 |
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