Altered neural correlates of episodic memory in adolescents with severe obesity

Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their asso...

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Autores principales: Pearce, Alaina L, Mackey, Eleanor, Cherry, J. Bradley C., Olson, Alexandra, You, Xiaozhen, Nadler, Evan P, Vaidya, Chandan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974906/
https://www.ncbi.nlm.nih.gov/pubmed/31839215
http://dx.doi.org/10.1016/j.dcn.2019.100727
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author Pearce, Alaina L
Mackey, Eleanor
Cherry, J. Bradley C.
Olson, Alexandra
You, Xiaozhen
Nadler, Evan P
Vaidya, Chandan J
author_facet Pearce, Alaina L
Mackey, Eleanor
Cherry, J. Bradley C.
Olson, Alexandra
You, Xiaozhen
Nadler, Evan P
Vaidya, Chandan J
author_sort Pearce, Alaina L
collection PubMed
description Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their associated context in adolescents with severe obesity (age 14–18 years, 43% male). Despite similar subsequent memory as adolescents without obesity (BMI for age and sex <95th percentile), those with severe obesity (BMI for age and sex 120% above the 95th percentile) showed reduced hippocampal, parahippocampal, frontal, and parietal engagement during encoding of remembered visual scenes and greater lateral temporal engagement during encoding of their associated context. Standardized testing revealed a trend level group difference in memory performance, with a larger magnitude of obesity-related difference in recollection-related memory that was mediated by individual differences in lateral temporal activation during contextual encoding. The observed widespread functional alterations are concerning in light of the importance of mnemonic processing for academic achievement and feeding behavior and underscore the need for prevention and intervention initiatives for pediatric obesity.
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spelling pubmed-69749062020-01-27 Altered neural correlates of episodic memory in adolescents with severe obesity Pearce, Alaina L Mackey, Eleanor Cherry, J. Bradley C. Olson, Alexandra You, Xiaozhen Nadler, Evan P Vaidya, Chandan J Dev Cogn Neurosci Original Research Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their associated context in adolescents with severe obesity (age 14–18 years, 43% male). Despite similar subsequent memory as adolescents without obesity (BMI for age and sex <95th percentile), those with severe obesity (BMI for age and sex 120% above the 95th percentile) showed reduced hippocampal, parahippocampal, frontal, and parietal engagement during encoding of remembered visual scenes and greater lateral temporal engagement during encoding of their associated context. Standardized testing revealed a trend level group difference in memory performance, with a larger magnitude of obesity-related difference in recollection-related memory that was mediated by individual differences in lateral temporal activation during contextual encoding. The observed widespread functional alterations are concerning in light of the importance of mnemonic processing for academic achievement and feeding behavior and underscore the need for prevention and intervention initiatives for pediatric obesity. Elsevier 2019-11-06 /pmc/articles/PMC6974906/ /pubmed/31839215 http://dx.doi.org/10.1016/j.dcn.2019.100727 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Pearce, Alaina L
Mackey, Eleanor
Cherry, J. Bradley C.
Olson, Alexandra
You, Xiaozhen
Nadler, Evan P
Vaidya, Chandan J
Altered neural correlates of episodic memory in adolescents with severe obesity
title Altered neural correlates of episodic memory in adolescents with severe obesity
title_full Altered neural correlates of episodic memory in adolescents with severe obesity
title_fullStr Altered neural correlates of episodic memory in adolescents with severe obesity
title_full_unstemmed Altered neural correlates of episodic memory in adolescents with severe obesity
title_short Altered neural correlates of episodic memory in adolescents with severe obesity
title_sort altered neural correlates of episodic memory in adolescents with severe obesity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974906/
https://www.ncbi.nlm.nih.gov/pubmed/31839215
http://dx.doi.org/10.1016/j.dcn.2019.100727
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