An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment?

AIM: We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). METHODS: Patients aged 65 or over with a diagnosis of GBM were identified from an 18-month period from three centers in the UK. The primary...

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Detalles Bibliográficos
Autores principales: Chong, Ming Yao, Lorimer, Cressida F, Mehta, Shaveta, Ibrahim, Ehab, Brock, Juliet, McBain, Catherine, McLoone, Philip, Chalmers, Anthony J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974914/
https://www.ncbi.nlm.nih.gov/pubmed/31818127
http://dx.doi.org/10.2217/cns-2019-0017
Descripción
Sumario:AIM: We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). METHODS: Patients aged 65 or over with a diagnosis of GBM were identified from an 18-month period from three centers in the UK. The primary end point of this study was overall survival from the date of diagnosis. RESULTS: The analysis included 210 patients. Overall median survival was 5.0 months. Approximately 31.9% of patients received combined chemoradiation; multivariate analysis showed that patients who received standard chemoradiation were at a reduced risk of death than those receiving hypofractionated chemoradiation. DISCUSSION: In this retrospective study, patients treated with standard chemoradiation experienced better outcomes than patients receiving hypofractionated chemoradiation. Patient selection likely contributed to these findings.

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