Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)

Nucleic acid–mediated protein–protein assembly (NAPPA) represents a true modular means for preparing multispecific antibodies (MsAbs). In article number https://doi.org/10.1002/advs.201900973, James J. Chou and co‐workers prepare MsAbs displaying T‐cell engaging and tumor killing properties in vivo....

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Liqiang, Cao, Chan, Run, Changqing, Zhou, Liujuan, Chou, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Inside Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974933/
http://dx.doi.org/10.1002/advs.202070010
_version_ 1783490197672951808
author Pan, Liqiang
Cao, Chan
Run, Changqing
Zhou, Liujuan
Chou, James J.
author_facet Pan, Liqiang
Cao, Chan
Run, Changqing
Zhou, Liujuan
Chou, James J.
author_sort Pan, Liqiang
collection PubMed
description Nucleic acid–mediated protein–protein assembly (NAPPA) represents a true modular means for preparing multispecific antibodies (MsAbs). In article number https://doi.org/10.1002/advs.201900973, James J. Chou and co‐workers prepare MsAbs displaying T‐cell engaging and tumor killing properties in vivo. NAPPA allows for the preparation of individual antibody modules separately, stored in an antibody library (middle cubic grid), which can be used to assemble a large variety of MsAbs immediately before use. [Image: see text]
format Online
Article
Text
id pubmed-6974933
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-69749332020-01-28 Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020) Pan, Liqiang Cao, Chan Run, Changqing Zhou, Liujuan Chou, James J. Adv Sci (Weinh) Inside Back Cover Nucleic acid–mediated protein–protein assembly (NAPPA) represents a true modular means for preparing multispecific antibodies (MsAbs). In article number https://doi.org/10.1002/advs.201900973, James J. Chou and co‐workers prepare MsAbs displaying T‐cell engaging and tumor killing properties in vivo. NAPPA allows for the preparation of individual antibody modules separately, stored in an antibody library (middle cubic grid), which can be used to assemble a large variety of MsAbs immediately before use. [Image: see text] John Wiley and Sons Inc. 2020-01-22 /pmc/articles/PMC6974933/ http://dx.doi.org/10.1002/advs.202070010 Text en © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Inside Back Cover
Pan, Liqiang
Cao, Chan
Run, Changqing
Zhou, Liujuan
Chou, James J.
Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)
title Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)
title_full Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)
title_fullStr Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)
title_full_unstemmed Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)
title_short Multispecific Antibodies: DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing (Adv. Sci. 2/2020)
title_sort multispecific antibodies: dna‐mediated assembly of multispecific antibodies for t cell engaging and tumor killing (adv. sci. 2/2020)
topic Inside Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974933/
http://dx.doi.org/10.1002/advs.202070010
work_keys_str_mv AT panliqiang multispecificantibodiesdnamediatedassemblyofmultispecificantibodiesfortcellengagingandtumorkillingadvsci22020
AT caochan multispecificantibodiesdnamediatedassemblyofmultispecificantibodiesfortcellengagingandtumorkillingadvsci22020
AT runchangqing multispecificantibodiesdnamediatedassemblyofmultispecificantibodiesfortcellengagingandtumorkillingadvsci22020
AT zhouliujuan multispecificantibodiesdnamediatedassemblyofmultispecificantibodiesfortcellengagingandtumorkillingadvsci22020
AT choujamesj multispecificantibodiesdnamediatedassemblyofmultispecificantibodiesfortcellengagingandtumorkillingadvsci22020

Ejemplares similares