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Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study

BACKGROUND: Literature shows association between systemic fluorides and endocrine disorders especially related to thyroid, with lack of clarity. AIMS AND OBJECTIVES: The aim and objective of this study was to estimate serum triiodothyronine (T3), thyroxin, thyroid-stimulating hormone (TSH), fluoride...

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Autores principales: Shaik, Naseemoon, Shanbhog, Raghavendra, Nandlal, B., Tippeswamy, H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974988/
https://www.ncbi.nlm.nih.gov/pubmed/32015637
http://dx.doi.org/10.4103/ccd.ccd_108_18
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author Shaik, Naseemoon
Shanbhog, Raghavendra
Nandlal, B.
Tippeswamy, H. M.
author_facet Shaik, Naseemoon
Shanbhog, Raghavendra
Nandlal, B.
Tippeswamy, H. M.
author_sort Shaik, Naseemoon
collection PubMed
description BACKGROUND: Literature shows association between systemic fluorides and endocrine disorders especially related to thyroid, with lack of clarity. AIMS AND OBJECTIVES: The aim and objective of this study was to estimate serum triiodothyronine (T3), thyroxin, thyroid-stimulating hormone (TSH), fluoride, calcium, phosphate, and alkaline phosphatase levels among children with normal nutritional status and optimal iodine intake residing in three different ranges of drinking water fluoride levels. MATERIALS AND METHODS: The present double-blinded, observational trial comprised of 293 children aged between 9 and 13 years consuming naturally fluoridated water of three different ranges: Group I: 0.01–0.6 parts per million (ppm), Group II: 0.7–1.2 ppm, and Group III: 1.3–1.8 ppm. For each child's demographic data, body mass index and Clinical Fluorosis Index were recorded along with serum T3, T4, TSH, fluoride, calcium, phosphate, and serum alkaline phosphatase levels. Data were analyzed using Chi–square test, Kruskal–Wallis test, and repeated measures ANOVA with SPSS 23. RESULTS: For serum TSH levels, 40% of children in Group I had deranged levels followed by Group III (20%) and Group II (16%). For serum T4 levels, 24% of children of both Groups I and III had deranged levels followed by Group II (20%). Intergroup correlation of drinking water fluoride levels to the number of deranged serum T3, T4, and TSH of the children showed nonsignificant association. Serum T3, calcium, phosphate, and alkaline phosphatase levels in all children showed values falling within normal range. CONCLUSION: According to the present study results, long-term intake of fluoridated drinking water (0.02–1.4 ppm) did not show effect on the thyroid function in children with normal nutritional status and optimal iodine intake.
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spelling pubmed-69749882020-02-03 Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study Shaik, Naseemoon Shanbhog, Raghavendra Nandlal, B. Tippeswamy, H. M. Contemp Clin Dent Original Article BACKGROUND: Literature shows association between systemic fluorides and endocrine disorders especially related to thyroid, with lack of clarity. AIMS AND OBJECTIVES: The aim and objective of this study was to estimate serum triiodothyronine (T3), thyroxin, thyroid-stimulating hormone (TSH), fluoride, calcium, phosphate, and alkaline phosphatase levels among children with normal nutritional status and optimal iodine intake residing in three different ranges of drinking water fluoride levels. MATERIALS AND METHODS: The present double-blinded, observational trial comprised of 293 children aged between 9 and 13 years consuming naturally fluoridated water of three different ranges: Group I: 0.01–0.6 parts per million (ppm), Group II: 0.7–1.2 ppm, and Group III: 1.3–1.8 ppm. For each child's demographic data, body mass index and Clinical Fluorosis Index were recorded along with serum T3, T4, TSH, fluoride, calcium, phosphate, and serum alkaline phosphatase levels. Data were analyzed using Chi–square test, Kruskal–Wallis test, and repeated measures ANOVA with SPSS 23. RESULTS: For serum TSH levels, 40% of children in Group I had deranged levels followed by Group III (20%) and Group II (16%). For serum T4 levels, 24% of children of both Groups I and III had deranged levels followed by Group II (20%). Intergroup correlation of drinking water fluoride levels to the number of deranged serum T3, T4, and TSH of the children showed nonsignificant association. Serum T3, calcium, phosphate, and alkaline phosphatase levels in all children showed values falling within normal range. CONCLUSION: According to the present study results, long-term intake of fluoridated drinking water (0.02–1.4 ppm) did not show effect on the thyroid function in children with normal nutritional status and optimal iodine intake. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6974988/ /pubmed/32015637 http://dx.doi.org/10.4103/ccd.ccd_108_18 Text en Copyright: © 2019 Contemporary Clinical Dentistry http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shaik, Naseemoon
Shanbhog, Raghavendra
Nandlal, B.
Tippeswamy, H. M.
Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study
title Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study
title_full Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study
title_fullStr Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study
title_full_unstemmed Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study
title_short Fluoride and Thyroid Function in Children Resident of Naturally Fluoridated Areas Consuming Different Levels of Fluoride in Drinking Water: An Observational Study
title_sort fluoride and thyroid function in children resident of naturally fluoridated areas consuming different levels of fluoride in drinking water: an observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974988/
https://www.ncbi.nlm.nih.gov/pubmed/32015637
http://dx.doi.org/10.4103/ccd.ccd_108_18
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