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A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan
BACKGROUND: The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. METHODS: A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, v...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975526/ https://www.ncbi.nlm.nih.gov/pubmed/31967989 http://dx.doi.org/10.1371/journal.pone.0225402 |
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author | Shamsi, Uzma Khan, Shaista Azam, Iqbal Habib Khan, Aysha Maqbool, Amir Hanif, Mohammad Gill, Tiffany Iqbal, Romaina Callen, David |
author_facet | Shamsi, Uzma Khan, Shaista Azam, Iqbal Habib Khan, Aysha Maqbool, Amir Hanif, Mohammad Gill, Tiffany Iqbal, Romaina Callen, David |
author_sort | Shamsi, Uzma |
collection | PubMed |
description | BACKGROUND: The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. METHODS: A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information was collected on sociodemographic history, history of vitamin D supplementation, past medical and obstetrical history, family history of breast cancer, sun exposure history, histopathology reports and anthropometric measurement and venous blood was collected to measure serum 25-hydroxyvitamin D (25(OH)D) concentration. RESULTS: Compared to patients with sufficient serum vitamin D (>30 ng/ml), women with serum vitamin D deficiency (<20ng/ml), had a higher risk of breast cancer (OR = 1.65, 95%CI: 1.10, 2.50). Women with history of vitamin D supplementation one year prior to enrollment, had significant protective effect against breast cancer (OR = 0.32, 95% CI: 0.24, 0.43). CONCLUSIONS AND RECOMMENDATION: Serum vitamin D deficiency was associated with increased risk of breast cancer, while vitamin D supplementation was associated with decreased risk of breast cancer. In Pakistani women, where vitamin D deficiency is common, raising and maintaining serum vitamin D at population level is a safe and affordable strategy. It may play a role in reducing the incidence of both vitamin D deficiency and breast cancer, particularly among poor women where the breast cancer mortality is highest due to limited resources for early detection, diagnosis, and treatment. The effects of vitamin D with regard to breast cancer risk in Karachi Pakistan should be further evaluated. |
format | Online Article Text |
id | pubmed-6975526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69755262020-02-04 A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan Shamsi, Uzma Khan, Shaista Azam, Iqbal Habib Khan, Aysha Maqbool, Amir Hanif, Mohammad Gill, Tiffany Iqbal, Romaina Callen, David PLoS One Research Article BACKGROUND: The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. METHODS: A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information was collected on sociodemographic history, history of vitamin D supplementation, past medical and obstetrical history, family history of breast cancer, sun exposure history, histopathology reports and anthropometric measurement and venous blood was collected to measure serum 25-hydroxyvitamin D (25(OH)D) concentration. RESULTS: Compared to patients with sufficient serum vitamin D (>30 ng/ml), women with serum vitamin D deficiency (<20ng/ml), had a higher risk of breast cancer (OR = 1.65, 95%CI: 1.10, 2.50). Women with history of vitamin D supplementation one year prior to enrollment, had significant protective effect against breast cancer (OR = 0.32, 95% CI: 0.24, 0.43). CONCLUSIONS AND RECOMMENDATION: Serum vitamin D deficiency was associated with increased risk of breast cancer, while vitamin D supplementation was associated with decreased risk of breast cancer. In Pakistani women, where vitamin D deficiency is common, raising and maintaining serum vitamin D at population level is a safe and affordable strategy. It may play a role in reducing the incidence of both vitamin D deficiency and breast cancer, particularly among poor women where the breast cancer mortality is highest due to limited resources for early detection, diagnosis, and treatment. The effects of vitamin D with regard to breast cancer risk in Karachi Pakistan should be further evaluated. Public Library of Science 2020-01-22 /pmc/articles/PMC6975526/ /pubmed/31967989 http://dx.doi.org/10.1371/journal.pone.0225402 Text en © 2020 Shamsi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shamsi, Uzma Khan, Shaista Azam, Iqbal Habib Khan, Aysha Maqbool, Amir Hanif, Mohammad Gill, Tiffany Iqbal, Romaina Callen, David A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan |
title | A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan |
title_full | A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan |
title_fullStr | A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan |
title_full_unstemmed | A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan |
title_short | A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan |
title_sort | multicenter case control study of association of vitamin d with breast cancer among women in karachi, pakistan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975526/ https://www.ncbi.nlm.nih.gov/pubmed/31967989 http://dx.doi.org/10.1371/journal.pone.0225402 |
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