Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance

Active efflux due to tripartite RND efflux pumps is an important mechanism of clinically relevant antibiotic resistance in Gram-negative bacteria. These pumps are also essential for Gram-negative pathogens to cause infection and form biofilms. They consist of an inner membrane RND transporter; a per...

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Detalles Bibliográficos
Autores principales: McNeil, Helen E., Alav, Ilyas, Torres, Ricardo Corona, Rossiter, Amanda E., Laycock, Eve, Legood, Simon, Kaur, Inderpreet, Davies, Matthew, Wand, Matthew, Webber, Mark A., Bavro, Vassiliy N., Blair, Jessica M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975555/
https://www.ncbi.nlm.nih.gov/pubmed/31877175
http://dx.doi.org/10.1371/journal.ppat.1008101

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