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Mutational effects of Cys113 on structural dynamics of Pin1
Pin1 is a peptidyl-prolyl isomerase (PPIase) which catalyzes cis/trans isomerization of pS/pT-P bond. Its activity is related to various cellular functions including suppression of Alzheimer’s disease. A cysteine residue C113 is known to be important for its PPIase activity; a mutation C113A reduced...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society of Japan (BSJ)
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976032/ https://www.ncbi.nlm.nih.gov/pubmed/31984197 http://dx.doi.org/10.2142/biophysico.16.0_452 |