Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR regulates misfolded protein clearance by preventing it release through exosomes and promoting lysosomal degradation of misfolded prion protein...

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Detalles Bibliográficos
Autores principales: Pataer, Apar, Ozpolat, Bulent, Shao, RuPing, Cashman, Neil R., Plotkin, Steven S., Samuel, Charles E., Lin, Steven H., Kabil, Nashwa N., Wang, Jing, Majidi, Mourad, Fang, Bingliang, Roth, Jack A., Vaporciyan, Ara A., Wistuba, Ignacio I., Hung, Mien-Chie, Swisher, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976521/
https://www.ncbi.nlm.nih.gov/pubmed/31554935
http://dx.doi.org/10.1038/s41388-019-1010-4

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