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Treatment evolution and improved survival in multiple myeloma in Taiwan

The incidence of multiple myeloma (MM) is increasing worldwide, but the rate of increase is greatest in Asia. Few data describe the epidemiology and treatment of MM in Asia. Building on a cohort study from 2007 to 2012 using the Taiwan National Healthcare Insurance Research database, we extended our...

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Autores principales: Tang, Chao-Hsiun, Hou, Hsin-An, Huang, Kuan-Chih, Qiu, Hong, Liu, Yanfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976543/
https://www.ncbi.nlm.nih.gov/pubmed/31802187
http://dx.doi.org/10.1007/s00277-019-03858-w
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author Tang, Chao-Hsiun
Hou, Hsin-An
Huang, Kuan-Chih
Qiu, Hong
Liu, Yanfang
author_facet Tang, Chao-Hsiun
Hou, Hsin-An
Huang, Kuan-Chih
Qiu, Hong
Liu, Yanfang
author_sort Tang, Chao-Hsiun
collection PubMed
description The incidence of multiple myeloma (MM) is increasing worldwide, but the rate of increase is greatest in Asia. Few data describe the epidemiology and treatment of MM in Asia. Building on a cohort study from 2007 to 2012 using the Taiwan National Healthcare Insurance Research database, we extended our analysis to estimate the disease burden and treatment patterns of patients with MM in Taiwan through 2015. A further 1664 patients with newly diagnosed MM from 2013 to 2015 (total 4387 patients from 2007 to 2015) were enrolled and followed up until death or end of the observation period (December 31, 2016), whichever occurred first. The age distribution of the 2013–2015 cohort was similar to that for previous years, but there were fewer men (52.1% versus 58.0%), and more patients had renal impairment at diagnosis (19.7% versus 16.4%). From 2007 to 2015, crude annual incidences per 100,000 population of newly diagnosed MM increased from 1.74 to 2.48 and age-adjusted incidences from 1.41 to 1.65. Crude all-cause mortality rates increased over time. Case fatality decreased from 25.5 to 18.3% and median survival increased from 2.10 to 3.12 years. From 2007 to 2015, the percentage of patients receiving first-line therapy with novel agents increased from 0.4 to 89.4%, autologous stem cell transplantation doubled, and chemotherapy use decreased by 81%. Comprehensive national data covering 9 years of follow-up demonstrate continuing change in the disease burden, treatment, and survival of MM in Taiwan. Despite increased use of new treatments, MM remains largely incurable. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00277-019-03858-w) contains supplementary material, which is available to authorized users.
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spelling pubmed-69765432020-02-03 Treatment evolution and improved survival in multiple myeloma in Taiwan Tang, Chao-Hsiun Hou, Hsin-An Huang, Kuan-Chih Qiu, Hong Liu, Yanfang Ann Hematol Original Article The incidence of multiple myeloma (MM) is increasing worldwide, but the rate of increase is greatest in Asia. Few data describe the epidemiology and treatment of MM in Asia. Building on a cohort study from 2007 to 2012 using the Taiwan National Healthcare Insurance Research database, we extended our analysis to estimate the disease burden and treatment patterns of patients with MM in Taiwan through 2015. A further 1664 patients with newly diagnosed MM from 2013 to 2015 (total 4387 patients from 2007 to 2015) were enrolled and followed up until death or end of the observation period (December 31, 2016), whichever occurred first. The age distribution of the 2013–2015 cohort was similar to that for previous years, but there were fewer men (52.1% versus 58.0%), and more patients had renal impairment at diagnosis (19.7% versus 16.4%). From 2007 to 2015, crude annual incidences per 100,000 population of newly diagnosed MM increased from 1.74 to 2.48 and age-adjusted incidences from 1.41 to 1.65. Crude all-cause mortality rates increased over time. Case fatality decreased from 25.5 to 18.3% and median survival increased from 2.10 to 3.12 years. From 2007 to 2015, the percentage of patients receiving first-line therapy with novel agents increased from 0.4 to 89.4%, autologous stem cell transplantation doubled, and chemotherapy use decreased by 81%. Comprehensive national data covering 9 years of follow-up demonstrate continuing change in the disease burden, treatment, and survival of MM in Taiwan. Despite increased use of new treatments, MM remains largely incurable. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00277-019-03858-w) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-12-05 2020 /pmc/articles/PMC6976543/ /pubmed/31802187 http://dx.doi.org/10.1007/s00277-019-03858-w Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Tang, Chao-Hsiun
Hou, Hsin-An
Huang, Kuan-Chih
Qiu, Hong
Liu, Yanfang
Treatment evolution and improved survival in multiple myeloma in Taiwan
title Treatment evolution and improved survival in multiple myeloma in Taiwan
title_full Treatment evolution and improved survival in multiple myeloma in Taiwan
title_fullStr Treatment evolution and improved survival in multiple myeloma in Taiwan
title_full_unstemmed Treatment evolution and improved survival in multiple myeloma in Taiwan
title_short Treatment evolution and improved survival in multiple myeloma in Taiwan
title_sort treatment evolution and improved survival in multiple myeloma in taiwan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976543/
https://www.ncbi.nlm.nih.gov/pubmed/31802187
http://dx.doi.org/10.1007/s00277-019-03858-w
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