Cargando…

Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery

Elective cardiac surgery has low procedural complications. However, about 40% of patients develop extracardiac complications including delirium and acute kidney injury. We hypothesized that inflammatory processes and immune cell activation might be associated with these complications. We therefore p...

Descripción completa

Detalles Bibliográficos
Autores principales: Mossanen, Jana C., Jansen, Tobias U., Pracht, Jessica, Liepelt, Anke, Buendgens, Lukas, Stoppe, Christian, Goetzenich, Andreas, Simon, Tim-Philipp, Autschbach, Rüdiger, Marx, Gernot, Tacke, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976615/
https://www.ncbi.nlm.nih.gov/pubmed/31969629
http://dx.doi.org/10.1038/s41598-020-57700-9
_version_ 1783490341144363008
author Mossanen, Jana C.
Jansen, Tobias U.
Pracht, Jessica
Liepelt, Anke
Buendgens, Lukas
Stoppe, Christian
Goetzenich, Andreas
Simon, Tim-Philipp
Autschbach, Rüdiger
Marx, Gernot
Tacke, Frank
author_facet Mossanen, Jana C.
Jansen, Tobias U.
Pracht, Jessica
Liepelt, Anke
Buendgens, Lukas
Stoppe, Christian
Goetzenich, Andreas
Simon, Tim-Philipp
Autschbach, Rüdiger
Marx, Gernot
Tacke, Frank
author_sort Mossanen, Jana C.
collection PubMed
description Elective cardiac surgery has low procedural complications. However, about 40% of patients develop extracardiac complications including delirium and acute kidney injury. We hypothesized that inflammatory processes and immune cell activation might be associated with these complications. We therefore prospectively included 104 patients undergoing cardiac surgery in our study. We assessed peripheral blood leukocyte populations by flow cytometry and circulating cytokines before operation, after surgery and at days one and four post-operatively. Patients undergoing cardiac surgery showed significantly elevated leukocytes and neutrophils after surgery. On the contrary, monocytes decreased after surgery and significantly increased at days 1 and 4, particularly classical (Mon1,CD14++CD16−) and intermediate (Mon2,CD14++CD16+) monocytes. While peripheral leukocyte subsets were unaltered in patients with infectious (n = 15) or cardiac complications (n = 31), post-operative leukocytes (p = 0.0016), neutrophils (p = 0.0061) and Mon2 (p = 0.0007) were clearly raised in patients developing extracardiac complications (n = 35). Using multiple logistic regression analyses, patient’s age, ICU days, number of blood transfusions and elevated post-surgery Mon2 independently predicted extracardiac complications. Our findings demonstrate that elevated Mon2 after cardiac surgery are associated with an increased risk for extracardiac complications. These findings might improve the risk estimation after cardiac operations and the role of Mon2 for inflammation in cardiac surgery.
format Online
Article
Text
id pubmed-6976615
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-69766152020-01-29 Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery Mossanen, Jana C. Jansen, Tobias U. Pracht, Jessica Liepelt, Anke Buendgens, Lukas Stoppe, Christian Goetzenich, Andreas Simon, Tim-Philipp Autschbach, Rüdiger Marx, Gernot Tacke, Frank Sci Rep Article Elective cardiac surgery has low procedural complications. However, about 40% of patients develop extracardiac complications including delirium and acute kidney injury. We hypothesized that inflammatory processes and immune cell activation might be associated with these complications. We therefore prospectively included 104 patients undergoing cardiac surgery in our study. We assessed peripheral blood leukocyte populations by flow cytometry and circulating cytokines before operation, after surgery and at days one and four post-operatively. Patients undergoing cardiac surgery showed significantly elevated leukocytes and neutrophils after surgery. On the contrary, monocytes decreased after surgery and significantly increased at days 1 and 4, particularly classical (Mon1,CD14++CD16−) and intermediate (Mon2,CD14++CD16+) monocytes. While peripheral leukocyte subsets were unaltered in patients with infectious (n = 15) or cardiac complications (n = 31), post-operative leukocytes (p = 0.0016), neutrophils (p = 0.0061) and Mon2 (p = 0.0007) were clearly raised in patients developing extracardiac complications (n = 35). Using multiple logistic regression analyses, patient’s age, ICU days, number of blood transfusions and elevated post-surgery Mon2 independently predicted extracardiac complications. Our findings demonstrate that elevated Mon2 after cardiac surgery are associated with an increased risk for extracardiac complications. These findings might improve the risk estimation after cardiac operations and the role of Mon2 for inflammation in cardiac surgery. Nature Publishing Group UK 2020-01-22 /pmc/articles/PMC6976615/ /pubmed/31969629 http://dx.doi.org/10.1038/s41598-020-57700-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mossanen, Jana C.
Jansen, Tobias U.
Pracht, Jessica
Liepelt, Anke
Buendgens, Lukas
Stoppe, Christian
Goetzenich, Andreas
Simon, Tim-Philipp
Autschbach, Rüdiger
Marx, Gernot
Tacke, Frank
Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery
title Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery
title_full Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery
title_fullStr Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery
title_full_unstemmed Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery
title_short Elevated circulating CD14(++)CD16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery
title_sort elevated circulating cd14(++)cd16(+) intermediate monocytes are independently associated with extracardiac complications after cardiac surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976615/
https://www.ncbi.nlm.nih.gov/pubmed/31969629
http://dx.doi.org/10.1038/s41598-020-57700-9
work_keys_str_mv AT mossanenjanac elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT jansentobiasu elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT prachtjessica elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT liepeltanke elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT buendgenslukas elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT stoppechristian elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT goetzenichandreas elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT simontimphilipp elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT autschbachrudiger elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT marxgernot elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery
AT tackefrank elevatedcirculatingcd14cd16intermediatemonocytesareindependentlyassociatedwithextracardiaccomplicationsaftercardiacsurgery