L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction

Bone resorption requires the formation of complex, actin-rich cytoskeletal structures. During the early phase of sealing ring formation by osteoclasts, L-plastin regulates actin-bundling to form the nascent sealing zones (NSZ). Here, we show that L-plastin knockout mice produce osteoclasts that are...

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Detalles Bibliográficos
Autores principales: Chellaiah, Meenakshi A., Moorer, Megan C., Majumdar, Sunipa, Aljohani, Hanan, Morley, Sharon C., Yingling, Vanessa, Stains, Joseph P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976634/
https://www.ncbi.nlm.nih.gov/pubmed/31993243
http://dx.doi.org/10.1038/s41413-019-0079-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976634/
https://www.ncbi.nlm.nih.gov/pubmed/31993243
http://dx.doi.org/10.1038/s41413-019-0079-2

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