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Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation

Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic...

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Autores principales: Dwi Putra, S. E., Reichetzeder, C., Hasan, A. A., Slowinski, T., Chu, C., Krämer, B. K., Kleuser, B., Hocher, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976643/
https://www.ncbi.nlm.nih.gov/pubmed/31969597
http://dx.doi.org/10.1038/s41598-020-57725-0
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author Dwi Putra, S. E.
Reichetzeder, C.
Hasan, A. A.
Slowinski, T.
Chu, C.
Krämer, B. K.
Kleuser, B.
Hocher, B.
author_facet Dwi Putra, S. E.
Reichetzeder, C.
Hasan, A. A.
Slowinski, T.
Chu, C.
Krämer, B. K.
Kleuser, B.
Hocher, B.
author_sort Dwi Putra, S. E.
collection PubMed
description Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DNA methylation. Several studies in recent years have demonstrated associations between altered patterns of DNA methylation and adverse birth outcomes. However, larger studies that reliably investigated global DNA methylation are lacking. The aim of this study was to characterize global placental DNA methylation in relationship to size for gestational age. Global DNA methylation was assessed in 1023 placental samples by LC-MS/MS. LGA offspring displayed significantly higher global placental DNA methylation compared to appropriate for gestational age (AGA; p < 0.001). ANCOVA analyses adjusted for known factors impacting on DNA methylation demonstrated an independent association between placental global DNA methylation and LGA births (p < 0.001). Tertile stratification according to global placental DNA methylation levels revealed a significantly higher frequency of LGA births in the third tertile. Furthermore, a multiple logistic regression analysis corrected for known factors influencing birth weight highlighted an independent positive association between global placental DNA methylation and the frequency of LGA births (p = 0.001).
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spelling pubmed-69766432020-01-29 Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation Dwi Putra, S. E. Reichetzeder, C. Hasan, A. A. Slowinski, T. Chu, C. Krämer, B. K. Kleuser, B. Hocher, B. Sci Rep Article Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DNA methylation. Several studies in recent years have demonstrated associations between altered patterns of DNA methylation and adverse birth outcomes. However, larger studies that reliably investigated global DNA methylation are lacking. The aim of this study was to characterize global placental DNA methylation in relationship to size for gestational age. Global DNA methylation was assessed in 1023 placental samples by LC-MS/MS. LGA offspring displayed significantly higher global placental DNA methylation compared to appropriate for gestational age (AGA; p < 0.001). ANCOVA analyses adjusted for known factors impacting on DNA methylation demonstrated an independent association between placental global DNA methylation and LGA births (p < 0.001). Tertile stratification according to global placental DNA methylation levels revealed a significantly higher frequency of LGA births in the third tertile. Furthermore, a multiple logistic regression analysis corrected for known factors influencing birth weight highlighted an independent positive association between global placental DNA methylation and the frequency of LGA births (p = 0.001). Nature Publishing Group UK 2020-01-22 /pmc/articles/PMC6976643/ /pubmed/31969597 http://dx.doi.org/10.1038/s41598-020-57725-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Dwi Putra, S. E.
Reichetzeder, C.
Hasan, A. A.
Slowinski, T.
Chu, C.
Krämer, B. K.
Kleuser, B.
Hocher, B.
Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation
title Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation
title_full Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation
title_fullStr Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation
title_full_unstemmed Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation
title_short Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation
title_sort being born large for gestational age is associated with increased global placental dna methylation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976643/
https://www.ncbi.nlm.nih.gov/pubmed/31969597
http://dx.doi.org/10.1038/s41598-020-57725-0
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