Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B

Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as show...

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Detalles Bibliográficos
Autores principales: Sapili, Hani, Ho, Chai San, Malagobadan, Sharan, Arshad, Norhafiza Mohd, Nagoor, Noor Hasima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976669/
https://www.ncbi.nlm.nih.gov/pubmed/31969640
http://dx.doi.org/10.1038/s41598-020-57781-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976669/
https://www.ncbi.nlm.nih.gov/pubmed/31969640
http://dx.doi.org/10.1038/s41598-020-57781-6

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