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New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram

AIM: During surgery, a non‐invasive and easy‐to‐use method is required for evaluating left ventricular status. The systolic time interval, including pre‐ejection period (PEP), of left ventricle has been known to be correlated with cardiac contractility. In this study, we focused on the non‐invasive...

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Autor principal: Yamashita, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976781/
https://www.ncbi.nlm.nih.gov/pubmed/31993209
http://dx.doi.org/10.1002/ams2.483
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author Yamashita, Koichi
author_facet Yamashita, Koichi
author_sort Yamashita, Koichi
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description AIM: During surgery, a non‐invasive and easy‐to‐use method is required for evaluating left ventricular status. The systolic time interval, including pre‐ejection period (PEP), of left ventricle has been known to be correlated with cardiac contractility. In this study, we focused on the non‐invasive time interval from the Q wave of an electrocardiogram to the third component in the first heart sound (QS(1)‐3rd) and evaluated the correlation between PEP and peak differentiated left ventricular pressure (LV dp/dt). METHODS: Six adult anesthetized pigs were intubated. Mechanical ventilation was started. An electrocardiogram, carotid artery blood pressure, left ventricular pressure, and phonocardiogram on the fourth left intercostal space were monitored using a polygraph system. Cardiac output was measured by the thermodilution method. Data were simultaneously measured at baseline and after the infusion of noradrenaline, nitroprusside, esmolol sulfate, and dobutamine, respectively. Data were analyzed by Spearman’s rank correlation coefficient using four‐quadrant plot analysis. RESULTS: A total of 270 points were simultaneously measured. The QS(1)‐3rd showed a significant correlation with PEP (QS(1)‐3rd = 7.62 + 0.92 PEP; ρ = 0.91, P < 0.0001). Concordance rate was 92% between PEP and QS(1)‐3rd (excluded zones were set within ± 5 ms). Both PEP and QS(1)‐3rd showed a good correlation with LV dp/dt (LV dp/dt = 3861.3–24.4 PEP; ρ = 0.85, P < 0.0001, LV dp/dt = 3763.6–23.5 QS(1)‐3rd; ρ = 0.82, P < 0.0001). CONCLUSION: This non‐invasive and easy‐to‐use hemodynamic parameter (QS(1)‐3rd) could be helpful for continuous monitoring of left cardiac contraction performance.
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spelling pubmed-69767812020-01-28 New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram Yamashita, Koichi Acute Med Surg Original Articles AIM: During surgery, a non‐invasive and easy‐to‐use method is required for evaluating left ventricular status. The systolic time interval, including pre‐ejection period (PEP), of left ventricle has been known to be correlated with cardiac contractility. In this study, we focused on the non‐invasive time interval from the Q wave of an electrocardiogram to the third component in the first heart sound (QS(1)‐3rd) and evaluated the correlation between PEP and peak differentiated left ventricular pressure (LV dp/dt). METHODS: Six adult anesthetized pigs were intubated. Mechanical ventilation was started. An electrocardiogram, carotid artery blood pressure, left ventricular pressure, and phonocardiogram on the fourth left intercostal space were monitored using a polygraph system. Cardiac output was measured by the thermodilution method. Data were simultaneously measured at baseline and after the infusion of noradrenaline, nitroprusside, esmolol sulfate, and dobutamine, respectively. Data were analyzed by Spearman’s rank correlation coefficient using four‐quadrant plot analysis. RESULTS: A total of 270 points were simultaneously measured. The QS(1)‐3rd showed a significant correlation with PEP (QS(1)‐3rd = 7.62 + 0.92 PEP; ρ = 0.91, P < 0.0001). Concordance rate was 92% between PEP and QS(1)‐3rd (excluded zones were set within ± 5 ms). Both PEP and QS(1)‐3rd showed a good correlation with LV dp/dt (LV dp/dt = 3861.3–24.4 PEP; ρ = 0.85, P < 0.0001, LV dp/dt = 3763.6–23.5 QS(1)‐3rd; ρ = 0.82, P < 0.0001). CONCLUSION: This non‐invasive and easy‐to‐use hemodynamic parameter (QS(1)‐3rd) could be helpful for continuous monitoring of left cardiac contraction performance. John Wiley and Sons Inc. 2020-01-22 /pmc/articles/PMC6976781/ /pubmed/31993209 http://dx.doi.org/10.1002/ams2.483 Text en © 2020 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Yamashita, Koichi
New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram
title New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram
title_full New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram
title_fullStr New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram
title_full_unstemmed New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram
title_short New non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram
title_sort new non‐invasive approach to detect cardiac contractility using the first sound of phonocardiogram
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976781/
https://www.ncbi.nlm.nih.gov/pubmed/31993209
http://dx.doi.org/10.1002/ams2.483
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