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High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy
Silica is an independent risk factor for lung cancer in addition to smoking. Chronic silicosis is one of the most common and serious occupational diseases associated with poor prognosis. However, the role of radiotherapy is unclear in patients with chronic silicosis. We conducted a retrospective stu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976816/ https://www.ncbi.nlm.nih.gov/pubmed/31822893 http://dx.doi.org/10.1093/jrr/rrz084 |
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author | Shen, Tianle Sheng, Liming Chen, Ying Cheng, Lei Du, Xianghui |
author_facet | Shen, Tianle Sheng, Liming Chen, Ying Cheng, Lei Du, Xianghui |
author_sort | Shen, Tianle |
collection | PubMed |
description | Silica is an independent risk factor for lung cancer in addition to smoking. Chronic silicosis is one of the most common and serious occupational diseases associated with poor prognosis. However, the role of radiotherapy is unclear in patients with chronic silicosis. We conducted a retrospective study to evaluate efficacy and safety in lung cancer patients with chronic silicosis, especially focusing on the incidence of radiation pneumonitis (RP). Lung cancer patients with chronic silicosis who had been treated with radiotherapy from 2005 to 2018 in our hospital were enrolled in this retrospective study. RP was graded according to the National Cancer Institute’s Common Terminology Criteria for Adverse Events (CTCAE), version 3.0. Of the 22 patients, ten (45.5%) developed RP ≥2. Two RP-related deaths (9.1%) occurred within 3 months after radiotherapy. Dosimetric factors V(5), V(10), V(15), V(20) and mean lung dose (MLD) were significantly higher in patients who had RP >2 (P < 0.05). The median overall survival times in patients with RP ≤2 and RP>2 were 11.5 months and 7.1 months, respectively. Radiotherapy is associated with excessive and fatal pulmonary toxicity in lung cancer patients with chronic silicosis. |
format | Online Article Text |
id | pubmed-6976816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-69768162020-01-27 High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy Shen, Tianle Sheng, Liming Chen, Ying Cheng, Lei Du, Xianghui J Radiat Res Regular Paper Silica is an independent risk factor for lung cancer in addition to smoking. Chronic silicosis is one of the most common and serious occupational diseases associated with poor prognosis. However, the role of radiotherapy is unclear in patients with chronic silicosis. We conducted a retrospective study to evaluate efficacy and safety in lung cancer patients with chronic silicosis, especially focusing on the incidence of radiation pneumonitis (RP). Lung cancer patients with chronic silicosis who had been treated with radiotherapy from 2005 to 2018 in our hospital were enrolled in this retrospective study. RP was graded according to the National Cancer Institute’s Common Terminology Criteria for Adverse Events (CTCAE), version 3.0. Of the 22 patients, ten (45.5%) developed RP ≥2. Two RP-related deaths (9.1%) occurred within 3 months after radiotherapy. Dosimetric factors V(5), V(10), V(15), V(20) and mean lung dose (MLD) were significantly higher in patients who had RP >2 (P < 0.05). The median overall survival times in patients with RP ≤2 and RP>2 were 11.5 months and 7.1 months, respectively. Radiotherapy is associated with excessive and fatal pulmonary toxicity in lung cancer patients with chronic silicosis. Oxford University Press 2019-12-10 /pmc/articles/PMC6976816/ /pubmed/31822893 http://dx.doi.org/10.1093/jrr/rrz084 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Paper Shen, Tianle Sheng, Liming Chen, Ying Cheng, Lei Du, Xianghui High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy |
title | High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy |
title_full | High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy |
title_fullStr | High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy |
title_full_unstemmed | High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy |
title_short | High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy |
title_sort | high incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy |
topic | Regular Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976816/ https://www.ncbi.nlm.nih.gov/pubmed/31822893 http://dx.doi.org/10.1093/jrr/rrz084 |
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