PIK3CA and PTEN Genes Expressions in Breast Cancer

BACKGROUND: The phosphatidylinositol-3 kinase (PI3K) intracellular signaling pathway plays an important role in breast cancer. The current study aimed to evaluate the expressions of two main regulators of PI3K pathway; phosphatidylinositol-3- kinase catalytic subunit alpha as activator (PIK3CA), and...

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Detalles Bibliográficos
Autores principales: Alowiri, Nabil Hadi, Hanafy, Shaden Muawia, Haleem, Reham Abdel, Abdellatif, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976819/
https://www.ncbi.nlm.nih.gov/pubmed/31554385
http://dx.doi.org/10.31557/APJCP.2019.20.9.2841
Descripción
Sumario:BACKGROUND: The phosphatidylinositol-3 kinase (PI3K) intracellular signaling pathway plays an important role in breast cancer. The current study aimed to evaluate the expressions of two main regulators of PI3K pathway; phosphatidylinositol-3- kinase catalytic subunit alpha as activator (PIK3CA), and phosphatase and tensin-homolog as inhibitor (PTEN), in breast carcinoma tissue, and compare with their expressions in adjacent normal breast tissue. METHODS: A total of fifty female patients with breast carcinoma from surgical oncology unit of Alexandria-Main University Hospital were included in this study. The Quantitative Real Time PCR was used to quantify expressions of PIK3CA and PTEN. RESULTS: PIK3CA mRNA expression was significantly increased in breast cancer tissues compared to normal breast tissues (P<0.001, Z=5.700), also PTEN mRNA expression was significantly higher in breast carcinoma tissue compared to normal breast tissue (P<0.001, Z=5.362). CONCLUSION: Increased the expressions of PIK3CA and PTEN mRNA in breast cancer tissue compared to normal breast tissue.

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