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PIK3CA and PTEN Genes Expressions in Breast Cancer

BACKGROUND: The phosphatidylinositol-3 kinase (PI3K) intracellular signaling pathway plays an important role in breast cancer. The current study aimed to evaluate the expressions of two main regulators of PI3K pathway; phosphatidylinositol-3- kinase catalytic subunit alpha as activator (PIK3CA), and...

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Autores principales: Alowiri, Nabil Hadi, Hanafy, Shaden Muawia, Haleem, Reham Abdel, Abdellatif, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976819/
https://www.ncbi.nlm.nih.gov/pubmed/31554385
http://dx.doi.org/10.31557/APJCP.2019.20.9.2841
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author Alowiri, Nabil Hadi
Hanafy, Shaden Muawia
Haleem, Reham Abdel
Abdellatif, Ahmed
author_facet Alowiri, Nabil Hadi
Hanafy, Shaden Muawia
Haleem, Reham Abdel
Abdellatif, Ahmed
author_sort Alowiri, Nabil Hadi
collection PubMed
description BACKGROUND: The phosphatidylinositol-3 kinase (PI3K) intracellular signaling pathway plays an important role in breast cancer. The current study aimed to evaluate the expressions of two main regulators of PI3K pathway; phosphatidylinositol-3- kinase catalytic subunit alpha as activator (PIK3CA), and phosphatase and tensin-homolog as inhibitor (PTEN), in breast carcinoma tissue, and compare with their expressions in adjacent normal breast tissue. METHODS: A total of fifty female patients with breast carcinoma from surgical oncology unit of Alexandria-Main University Hospital were included in this study. The Quantitative Real Time PCR was used to quantify expressions of PIK3CA and PTEN. RESULTS: PIK3CA mRNA expression was significantly increased in breast cancer tissues compared to normal breast tissues (P<0.001, Z=5.700), also PTEN mRNA expression was significantly higher in breast carcinoma tissue compared to normal breast tissue (P<0.001, Z=5.362). CONCLUSION: Increased the expressions of PIK3CA and PTEN mRNA in breast cancer tissue compared to normal breast tissue.
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spelling pubmed-69768192020-02-04 PIK3CA and PTEN Genes Expressions in Breast Cancer Alowiri, Nabil Hadi Hanafy, Shaden Muawia Haleem, Reham Abdel Abdellatif, Ahmed Asian Pac J Cancer Prev Research Article BACKGROUND: The phosphatidylinositol-3 kinase (PI3K) intracellular signaling pathway plays an important role in breast cancer. The current study aimed to evaluate the expressions of two main regulators of PI3K pathway; phosphatidylinositol-3- kinase catalytic subunit alpha as activator (PIK3CA), and phosphatase and tensin-homolog as inhibitor (PTEN), in breast carcinoma tissue, and compare with their expressions in adjacent normal breast tissue. METHODS: A total of fifty female patients with breast carcinoma from surgical oncology unit of Alexandria-Main University Hospital were included in this study. The Quantitative Real Time PCR was used to quantify expressions of PIK3CA and PTEN. RESULTS: PIK3CA mRNA expression was significantly increased in breast cancer tissues compared to normal breast tissues (P<0.001, Z=5.700), also PTEN mRNA expression was significantly higher in breast carcinoma tissue compared to normal breast tissue (P<0.001, Z=5.362). CONCLUSION: Increased the expressions of PIK3CA and PTEN mRNA in breast cancer tissue compared to normal breast tissue. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6976819/ /pubmed/31554385 http://dx.doi.org/10.31557/APJCP.2019.20.9.2841 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alowiri, Nabil Hadi
Hanafy, Shaden Muawia
Haleem, Reham Abdel
Abdellatif, Ahmed
PIK3CA and PTEN Genes Expressions in Breast Cancer
title PIK3CA and PTEN Genes Expressions in Breast Cancer
title_full PIK3CA and PTEN Genes Expressions in Breast Cancer
title_fullStr PIK3CA and PTEN Genes Expressions in Breast Cancer
title_full_unstemmed PIK3CA and PTEN Genes Expressions in Breast Cancer
title_short PIK3CA and PTEN Genes Expressions in Breast Cancer
title_sort pik3ca and pten genes expressions in breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976819/
https://www.ncbi.nlm.nih.gov/pubmed/31554385
http://dx.doi.org/10.31557/APJCP.2019.20.9.2841
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