Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines

OBJECTIVE: In the study our aim was to evaluate the cytotoxic activity of different solvent extracts of Annona squamosa seeds. METHODS AND MATERIALS: The four extracts used were petroleum ether, chloroform, ethyl acetate and methanol were tested using cytotoxicity assays. RESULTS: Among the four ext...

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Detalles Bibliográficos
Autores principales: Vikas, Biba, Anil, Sukumaran, Remani, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976856/
https://www.ncbi.nlm.nih.gov/pubmed/31554384
http://dx.doi.org/10.31557/APJCP.2019.20.9.2831
Descripción
Sumario:OBJECTIVE: In the study our aim was to evaluate the cytotoxic activity of different solvent extracts of Annona squamosa seeds. METHODS AND MATERIALS: The four extracts used were petroleum ether, chloroform, ethyl acetate and methanol were tested using cytotoxicity assays. RESULTS: Among the four extracts tested petroleum ether showed maximum cytotoxicity against a panel of cancer cell lines such as nasopharyngeal cancer (KB) cells, lung cancer (A-549) cells, breast cancer (MCF- 7) cells, leukemic (K-562) cells and inhibited the growth of murine cancer cells such as Dalton’s lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC). CONCLUSION: Petroleum ether extract of Annona squamosa seeds showed cytotoxicity towards a panel of cancer cells meanwhile non-significant cytotoxicity towards normal cells.

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