Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines

OBJECTIVE: In the study our aim was to evaluate the cytotoxic activity of different solvent extracts of Annona squamosa seeds. METHODS AND MATERIALS: The four extracts used were petroleum ether, chloroform, ethyl acetate and methanol were tested using cytotoxicity assays. RESULTS: Among the four ext...

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Detalles Bibliográficos
Autores principales: Vikas, Biba, Anil, Sukumaran, Remani, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976856/
https://www.ncbi.nlm.nih.gov/pubmed/31554384
http://dx.doi.org/10.31557/APJCP.2019.20.9.2831
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author Vikas, Biba
Anil, Sukumaran
Remani, P
author_facet Vikas, Biba
Anil, Sukumaran
Remani, P
author_sort Vikas, Biba
collection PubMed
description OBJECTIVE: In the study our aim was to evaluate the cytotoxic activity of different solvent extracts of Annona squamosa seeds. METHODS AND MATERIALS: The four extracts used were petroleum ether, chloroform, ethyl acetate and methanol were tested using cytotoxicity assays. RESULTS: Among the four extracts tested petroleum ether showed maximum cytotoxicity against a panel of cancer cell lines such as nasopharyngeal cancer (KB) cells, lung cancer (A-549) cells, breast cancer (MCF- 7) cells, leukemic (K-562) cells and inhibited the growth of murine cancer cells such as Dalton’s lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC). CONCLUSION: Petroleum ether extract of Annona squamosa seeds showed cytotoxicity towards a panel of cancer cells meanwhile non-significant cytotoxicity towards normal cells.
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spelling pubmed-69768562020-02-04 Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines Vikas, Biba Anil, Sukumaran Remani, P Asian Pac J Cancer Prev Research Article OBJECTIVE: In the study our aim was to evaluate the cytotoxic activity of different solvent extracts of Annona squamosa seeds. METHODS AND MATERIALS: The four extracts used were petroleum ether, chloroform, ethyl acetate and methanol were tested using cytotoxicity assays. RESULTS: Among the four extracts tested petroleum ether showed maximum cytotoxicity against a panel of cancer cell lines such as nasopharyngeal cancer (KB) cells, lung cancer (A-549) cells, breast cancer (MCF- 7) cells, leukemic (K-562) cells and inhibited the growth of murine cancer cells such as Dalton’s lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC). CONCLUSION: Petroleum ether extract of Annona squamosa seeds showed cytotoxicity towards a panel of cancer cells meanwhile non-significant cytotoxicity towards normal cells. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6976856/ /pubmed/31554384 http://dx.doi.org/10.31557/APJCP.2019.20.9.2831 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vikas, Biba
Anil, Sukumaran
Remani, P
Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines
title Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines
title_full Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines
title_fullStr Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines
title_full_unstemmed Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines
title_short Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines
title_sort cytotoxicity profiling of annona squamosa in cancer cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976856/
https://www.ncbi.nlm.nih.gov/pubmed/31554384
http://dx.doi.org/10.31557/APJCP.2019.20.9.2831
work_keys_str_mv AT vikasbiba cytotoxicityprofilingofannonasquamosaincancercelllines
AT anilsukumaran cytotoxicityprofilingofannonasquamosaincancercelllines
AT remanip cytotoxicityprofilingofannonasquamosaincancercelllines

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