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Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model

Zebrafish (Danio rerio) has appeared as a valuable and popular model species to study the developmental and toxicological impact of environmental pollutants. To get insights on the toxicological effect of arsenic on early embryonic development, a controlled breeding of local Bangladeshi zebrafish fo...

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Autores principales: Kabir, Tamanna, Anwar, Saeed, Taslem Mourosi, Jarin, Hossain, Jakir, Rabbane, Md. Golam, Rahman, Md. Masuder, Tahsin, Tohura, Hasan, Md. Nazmul, Shill, Manik Chandra, Hosen, Mohammad Jakir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976906/
https://www.ncbi.nlm.nih.gov/pubmed/31993334
http://dx.doi.org/10.1016/j.toxrep.2019.12.009
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author Kabir, Tamanna
Anwar, Saeed
Taslem Mourosi, Jarin
Hossain, Jakir
Rabbane, Md. Golam
Rahman, Md. Masuder
Tahsin, Tohura
Hasan, Md. Nazmul
Shill, Manik Chandra
Hosen, Mohammad Jakir
author_facet Kabir, Tamanna
Anwar, Saeed
Taslem Mourosi, Jarin
Hossain, Jakir
Rabbane, Md. Golam
Rahman, Md. Masuder
Tahsin, Tohura
Hasan, Md. Nazmul
Shill, Manik Chandra
Hosen, Mohammad Jakir
author_sort Kabir, Tamanna
collection PubMed
description Zebrafish (Danio rerio) has appeared as a valuable and popular model species to study the developmental and toxicological impact of environmental pollutants. To get insights on the toxicological effect of arsenic on early embryonic development, a controlled breeding of local Bangladeshi zebrafish followed by comprehensive microscopic analysis was conducted to study the embryonic development after exposure to different concentrations of arsenic ranges from 4−120 h post-fertilization. Zebrafish embryos exposed to 2 mM of arsenic displayed distinguishable developmental delay compared to control. At three days post-fertilization, a distinct phenotype appears in arsenic-treated embryos, which can be characterized by dechorionated embryos, larger egg mass, pericardial edema, abnormal heart rate, and abnormal head development. Remarkably, the death rate of the arsenic-treated embryos was significantly higher compared to control. Collectively, these findings indicate that exposure to arsenic may result in abnormal embryonic development. These results suggest for proper management of the pregnant mother in the arsenic-exposed area, and may also explain the incidence of increased miscarriage/abortion rate in arsenic water drinking pregnant mother.
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spelling pubmed-69769062020-01-28 Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model Kabir, Tamanna Anwar, Saeed Taslem Mourosi, Jarin Hossain, Jakir Rabbane, Md. Golam Rahman, Md. Masuder Tahsin, Tohura Hasan, Md. Nazmul Shill, Manik Chandra Hosen, Mohammad Jakir Toxicol Rep Regular Article Zebrafish (Danio rerio) has appeared as a valuable and popular model species to study the developmental and toxicological impact of environmental pollutants. To get insights on the toxicological effect of arsenic on early embryonic development, a controlled breeding of local Bangladeshi zebrafish followed by comprehensive microscopic analysis was conducted to study the embryonic development after exposure to different concentrations of arsenic ranges from 4−120 h post-fertilization. Zebrafish embryos exposed to 2 mM of arsenic displayed distinguishable developmental delay compared to control. At three days post-fertilization, a distinct phenotype appears in arsenic-treated embryos, which can be characterized by dechorionated embryos, larger egg mass, pericardial edema, abnormal heart rate, and abnormal head development. Remarkably, the death rate of the arsenic-treated embryos was significantly higher compared to control. Collectively, these findings indicate that exposure to arsenic may result in abnormal embryonic development. These results suggest for proper management of the pregnant mother in the arsenic-exposed area, and may also explain the incidence of increased miscarriage/abortion rate in arsenic water drinking pregnant mother. Elsevier 2020-01-11 /pmc/articles/PMC6976906/ /pubmed/31993334 http://dx.doi.org/10.1016/j.toxrep.2019.12.009 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Kabir, Tamanna
Anwar, Saeed
Taslem Mourosi, Jarin
Hossain, Jakir
Rabbane, Md. Golam
Rahman, Md. Masuder
Tahsin, Tohura
Hasan, Md. Nazmul
Shill, Manik Chandra
Hosen, Mohammad Jakir
Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model
title Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model
title_full Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model
title_fullStr Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model
title_full_unstemmed Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model
title_short Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model
title_sort arsenic hampered embryonic development: an in vivo study using local bangladeshi danio rerio model
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976906/
https://www.ncbi.nlm.nih.gov/pubmed/31993334
http://dx.doi.org/10.1016/j.toxrep.2019.12.009
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