Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers

Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene. However, the composition and distribution of mutant p53 oligomers are unknown and the mechanism involved in the conv...

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Detalles Bibliográficos
Autores principales: Pedrote, Murilo M., Motta, Michelle F., Ferretti, Giulia D.S., Norberto, Douglas R., Spohr, Tania C.L.S., Lima, Flavia R.S., Gratton, Enrico, Silva, Jerson L., de Oliveira, Guilherme A.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976948/
https://www.ncbi.nlm.nih.gov/pubmed/31981923
http://dx.doi.org/10.1016/j.isci.2020.100820

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