Intraoperative ureter visualization using a near-infrared imaging agent

The fluorescent imaging agent IS-001 was determined to be well tolerated in all subjects and has the potential to provide ureter visualization throughout minimally invasive hysterectomy procedures. This study was conducted to evaluate clinical safety and efficacy of a real-time ureter visualization...

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Detalles Bibliográficos
Autores principales: Farnam, Richard W., Arms, Richard G., Klaassen, Alwin H., Sorger, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2019
Materias:
Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977010/
https://www.ncbi.nlm.nih.gov/pubmed/31215195
http://dx.doi.org/10.1117/1.JBO.24.6.066004
Descripción
Sumario:The fluorescent imaging agent IS-001 was determined to be well tolerated in all subjects and has the potential to provide ureter visualization throughout minimally invasive hysterectomy procedures. This study was conducted to evaluate clinical safety and efficacy of a real-time ureter visualization technique for use during hysterectomy surgery. The study drug appears safe, is renally excreted, and allows enhanced ureter visualization when imaged with a clinically approved near-infrared sensitive endoscope. This is a first-in-human study showing preliminary results that the drug is safe and effective during surgery for improved ureter visualization.

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