Cargando…

Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses

Plasmonic nanoparticles (PNPs) continue to see increasing use in biophotonics for a variety of applications, including cancer detection and treatment. Several PNP-based approaches involve the generation of highly transient nanobubbles due to pulsed laser-induced vaporization and cavitation. While mu...

Descripción completa

Detalles Bibliográficos
Autores principales: Fales, Andrew M., Vogt, William C., Wear, Keith A., Pfefer, T. Joshua, Ilev, Ilko K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977022/
https://www.ncbi.nlm.nih.gov/pubmed/31230425
http://dx.doi.org/10.1117/1.JBO.24.6.065003
_version_ 1783490420533100544
author Fales, Andrew M.
Vogt, William C.
Wear, Keith A.
Pfefer, T. Joshua
Ilev, Ilko K.
author_facet Fales, Andrew M.
Vogt, William C.
Wear, Keith A.
Pfefer, T. Joshua
Ilev, Ilko K.
author_sort Fales, Andrew M.
collection PubMed
description Plasmonic nanoparticles (PNPs) continue to see increasing use in biophotonics for a variety of applications, including cancer detection and treatment. Several PNP-based approaches involve the generation of highly transient nanobubbles due to pulsed laser-induced vaporization and cavitation. While much effort has been devoted to elucidating the mechanisms behind bubble generation with spherical gold nano particles, the effects of particle shape on bubble generation thresholds are not well understood, especially in the nanosecond pulse regime. Our study aims to compare the bubble generation thresholds of gold nanospheres, gold nanorods, and silica-core gold nanoshells with different sizes, resonances, and surface coatings. Bubble generation is detected using a multimodality microscopy platform for simultaneous, nanosecond resolution pump-probe imaging, integrated scattering response, and acoustic transient detection. Nanoshells and large (40-nm width) nanorods were found to have the lowest thresholds for bubble generation, and in some cases they generated bubbles at radiant exposures below standard laser safety limits for skin exposure. This has important implications for both safety and performance of techniques employing pulsed lasers and PNPs.
format Online
Article
Text
id pubmed-6977022
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Society of Photo-Optical Instrumentation Engineers
record_format MEDLINE/PubMed
spelling pubmed-69770222020-02-03 Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses Fales, Andrew M. Vogt, William C. Wear, Keith A. Pfefer, T. Joshua Ilev, Ilko K. J Biomed Opt General Plasmonic nanoparticles (PNPs) continue to see increasing use in biophotonics for a variety of applications, including cancer detection and treatment. Several PNP-based approaches involve the generation of highly transient nanobubbles due to pulsed laser-induced vaporization and cavitation. While much effort has been devoted to elucidating the mechanisms behind bubble generation with spherical gold nano particles, the effects of particle shape on bubble generation thresholds are not well understood, especially in the nanosecond pulse regime. Our study aims to compare the bubble generation thresholds of gold nanospheres, gold nanorods, and silica-core gold nanoshells with different sizes, resonances, and surface coatings. Bubble generation is detected using a multimodality microscopy platform for simultaneous, nanosecond resolution pump-probe imaging, integrated scattering response, and acoustic transient detection. Nanoshells and large (40-nm width) nanorods were found to have the lowest thresholds for bubble generation, and in some cases they generated bubbles at radiant exposures below standard laser safety limits for skin exposure. This has important implications for both safety and performance of techniques employing pulsed lasers and PNPs. Society of Photo-Optical Instrumentation Engineers 2019-06-22 2019-06 /pmc/articles/PMC6977022/ /pubmed/31230425 http://dx.doi.org/10.1117/1.JBO.24.6.065003 Text en © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle General
Fales, Andrew M.
Vogt, William C.
Wear, Keith A.
Pfefer, T. Joshua
Ilev, Ilko K.
Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses
title Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses
title_full Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses
title_fullStr Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses
title_full_unstemmed Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses
title_short Experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses
title_sort experimental investigation of parameters influencing plasmonic nanoparticle-mediated bubble generation with nanosecond laser pulses
topic General
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977022/
https://www.ncbi.nlm.nih.gov/pubmed/31230425
http://dx.doi.org/10.1117/1.JBO.24.6.065003
work_keys_str_mv AT falesandrewm experimentalinvestigationofparametersinfluencingplasmonicnanoparticlemediatedbubblegenerationwithnanosecondlaserpulses
AT vogtwilliamc experimentalinvestigationofparametersinfluencingplasmonicnanoparticlemediatedbubblegenerationwithnanosecondlaserpulses
AT wearkeitha experimentalinvestigationofparametersinfluencingplasmonicnanoparticlemediatedbubblegenerationwithnanosecondlaserpulses
AT pfefertjoshua experimentalinvestigationofparametersinfluencingplasmonicnanoparticlemediatedbubblegenerationwithnanosecondlaserpulses
AT ilevilkok experimentalinvestigationofparametersinfluencingplasmonicnanoparticlemediatedbubblegenerationwithnanosecondlaserpulses