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Orofacial Muscles: Embryonic Development and Regeneration after Injury

Orofacial congenital defects such as cleft lip and/or palate are associated with impaired muscle regeneration and fibrosis after surgery. Also, other orofacial reconstructions or trauma may end up in defective muscle regeneration and fibrosis. The aim of this review is to discuss current knowledge o...

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Autores principales: Rosero Salazar, D.H., Carvajal Monroy, P.L., Wagener, F.A.D.T.G., Von den Hoff, J.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977159/
https://www.ncbi.nlm.nih.gov/pubmed/31675262
http://dx.doi.org/10.1177/0022034519883673
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author Rosero Salazar, D.H.
Carvajal Monroy, P.L.
Wagener, F.A.D.T.G.
Von den Hoff, J.W.
author_facet Rosero Salazar, D.H.
Carvajal Monroy, P.L.
Wagener, F.A.D.T.G.
Von den Hoff, J.W.
author_sort Rosero Salazar, D.H.
collection PubMed
description Orofacial congenital defects such as cleft lip and/or palate are associated with impaired muscle regeneration and fibrosis after surgery. Also, other orofacial reconstructions or trauma may end up in defective muscle regeneration and fibrosis. The aim of this review is to discuss current knowledge on the development and regeneration of orofacial muscles in comparison to trunk and limb muscles. The orofacial muscles include the tongue muscles and the branchiomeric muscles in the lower face. Their main functions are chewing, swallowing, and speech. All orofacial muscles originate from the mesoderm of the pharyngeal arches under the control of cranial neural crest cells. Research in vertebrate models indicates that the molecular regulation of orofacial muscle development is different from that of trunk and limb muscles. In addition, the regenerative ability of orofacial muscles is lower, and they develop more fibrosis than other skeletal muscles. Therefore, specific approaches need to be developed to stimulate orofacial muscle regeneration. Regeneration may be stimulated by growth factors such fibroblast growth factors and hepatocyte growth factor, while fibrosis may be reduced by targeting the transforming growth factor β1 (TGFβ1)/myofibroblast axis. New approaches that combine these 2 aspects will improve the surgical treatment of orofacial muscle defects.
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spelling pubmed-69771592020-02-07 Orofacial Muscles: Embryonic Development and Regeneration after Injury Rosero Salazar, D.H. Carvajal Monroy, P.L. Wagener, F.A.D.T.G. Von den Hoff, J.W. J Dent Res Reviews Orofacial congenital defects such as cleft lip and/or palate are associated with impaired muscle regeneration and fibrosis after surgery. Also, other orofacial reconstructions or trauma may end up in defective muscle regeneration and fibrosis. The aim of this review is to discuss current knowledge on the development and regeneration of orofacial muscles in comparison to trunk and limb muscles. The orofacial muscles include the tongue muscles and the branchiomeric muscles in the lower face. Their main functions are chewing, swallowing, and speech. All orofacial muscles originate from the mesoderm of the pharyngeal arches under the control of cranial neural crest cells. Research in vertebrate models indicates that the molecular regulation of orofacial muscle development is different from that of trunk and limb muscles. In addition, the regenerative ability of orofacial muscles is lower, and they develop more fibrosis than other skeletal muscles. Therefore, specific approaches need to be developed to stimulate orofacial muscle regeneration. Regeneration may be stimulated by growth factors such fibroblast growth factors and hepatocyte growth factor, while fibrosis may be reduced by targeting the transforming growth factor β1 (TGFβ1)/myofibroblast axis. New approaches that combine these 2 aspects will improve the surgical treatment of orofacial muscle defects. SAGE Publications 2019-11-01 2020-02 /pmc/articles/PMC6977159/ /pubmed/31675262 http://dx.doi.org/10.1177/0022034519883673 Text en © International & American Associations for Dental Research 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Rosero Salazar, D.H.
Carvajal Monroy, P.L.
Wagener, F.A.D.T.G.
Von den Hoff, J.W.
Orofacial Muscles: Embryonic Development and Regeneration after Injury
title Orofacial Muscles: Embryonic Development and Regeneration after Injury
title_full Orofacial Muscles: Embryonic Development and Regeneration after Injury
title_fullStr Orofacial Muscles: Embryonic Development and Regeneration after Injury
title_full_unstemmed Orofacial Muscles: Embryonic Development and Regeneration after Injury
title_short Orofacial Muscles: Embryonic Development and Regeneration after Injury
title_sort orofacial muscles: embryonic development and regeneration after injury
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977159/
https://www.ncbi.nlm.nih.gov/pubmed/31675262
http://dx.doi.org/10.1177/0022034519883673
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