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Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters

Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket...

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Autores principales: Panezai, Jeneen, Altamash, Mohammad, Engstrӧm, Per-Erik, Larsson, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977320/
https://www.ncbi.nlm.nih.gov/pubmed/31998807
http://dx.doi.org/10.1155/2020/6450742
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author Panezai, Jeneen
Altamash, Mohammad
Engstrӧm, Per-Erik
Larsson, Anders
author_facet Panezai, Jeneen
Altamash, Mohammad
Engstrӧm, Per-Erik
Larsson, Anders
author_sort Panezai, Jeneen
collection PubMed
description Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket depth (PPD) measurements. PPD total and PPD disease with and without tooth adjustment were used as continuous indices. Marginal bone loss (MBL) for mandibular premolars and molars was measured digitally. Body mass index (BMI) and waist circumference (WC) were also analyzed. Glycated hemoglobin (HbA1c) and fructosamine (FrAm) levels were measured in all subjects. A multiplex proximity extension assay (PEA) was used to analyze the serum samples for simultaneous measurement of 92 proteins. Both HbA1c and FrAm inversely correlated with IL-10, FGF-21, MCP-1, and TNF beta amongst 16 proteins. HbA1c correlated directly with OPG. Parameters of disease severity were consistently significant for HbA1c. Adjusted PPD total and number of missing teeth were increased in diabetes whereas levels of RANKL and RANKL to OPG ratio were the highest in nondiabetic periodontitis patients. Hyperglycemic conditions in periodontitis patients are associated with reduced levels of anti-inflammatory proteins as well as dysregulated bone resorption.
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spelling pubmed-69773202020-01-29 Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters Panezai, Jeneen Altamash, Mohammad Engstrӧm, Per-Erik Larsson, Anders J Diabetes Res Research Article Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket depth (PPD) measurements. PPD total and PPD disease with and without tooth adjustment were used as continuous indices. Marginal bone loss (MBL) for mandibular premolars and molars was measured digitally. Body mass index (BMI) and waist circumference (WC) were also analyzed. Glycated hemoglobin (HbA1c) and fructosamine (FrAm) levels were measured in all subjects. A multiplex proximity extension assay (PEA) was used to analyze the serum samples for simultaneous measurement of 92 proteins. Both HbA1c and FrAm inversely correlated with IL-10, FGF-21, MCP-1, and TNF beta amongst 16 proteins. HbA1c correlated directly with OPG. Parameters of disease severity were consistently significant for HbA1c. Adjusted PPD total and number of missing teeth were increased in diabetes whereas levels of RANKL and RANKL to OPG ratio were the highest in nondiabetic periodontitis patients. Hyperglycemic conditions in periodontitis patients are associated with reduced levels of anti-inflammatory proteins as well as dysregulated bone resorption. Hindawi 2020-01-10 /pmc/articles/PMC6977320/ /pubmed/31998807 http://dx.doi.org/10.1155/2020/6450742 Text en Copyright © 2020 Jeneen Panezai et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Panezai, Jeneen
Altamash, Mohammad
Engstrӧm, Per-Erik
Larsson, Anders
Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
title Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
title_full Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
title_fullStr Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
title_full_unstemmed Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
title_short Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
title_sort association of glycated proteins with inflammatory proteins and periodontal disease parameters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977320/
https://www.ncbi.nlm.nih.gov/pubmed/31998807
http://dx.doi.org/10.1155/2020/6450742
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