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Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977320/ https://www.ncbi.nlm.nih.gov/pubmed/31998807 http://dx.doi.org/10.1155/2020/6450742 |
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author | Panezai, Jeneen Altamash, Mohammad Engstrӧm, Per-Erik Larsson, Anders |
author_facet | Panezai, Jeneen Altamash, Mohammad Engstrӧm, Per-Erik Larsson, Anders |
author_sort | Panezai, Jeneen |
collection | PubMed |
description | Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket depth (PPD) measurements. PPD total and PPD disease with and without tooth adjustment were used as continuous indices. Marginal bone loss (MBL) for mandibular premolars and molars was measured digitally. Body mass index (BMI) and waist circumference (WC) were also analyzed. Glycated hemoglobin (HbA1c) and fructosamine (FrAm) levels were measured in all subjects. A multiplex proximity extension assay (PEA) was used to analyze the serum samples for simultaneous measurement of 92 proteins. Both HbA1c and FrAm inversely correlated with IL-10, FGF-21, MCP-1, and TNF beta amongst 16 proteins. HbA1c correlated directly with OPG. Parameters of disease severity were consistently significant for HbA1c. Adjusted PPD total and number of missing teeth were increased in diabetes whereas levels of RANKL and RANKL to OPG ratio were the highest in nondiabetic periodontitis patients. Hyperglycemic conditions in periodontitis patients are associated with reduced levels of anti-inflammatory proteins as well as dysregulated bone resorption. |
format | Online Article Text |
id | pubmed-6977320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-69773202020-01-29 Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters Panezai, Jeneen Altamash, Mohammad Engstrӧm, Per-Erik Larsson, Anders J Diabetes Res Research Article Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket depth (PPD) measurements. PPD total and PPD disease with and without tooth adjustment were used as continuous indices. Marginal bone loss (MBL) for mandibular premolars and molars was measured digitally. Body mass index (BMI) and waist circumference (WC) were also analyzed. Glycated hemoglobin (HbA1c) and fructosamine (FrAm) levels were measured in all subjects. A multiplex proximity extension assay (PEA) was used to analyze the serum samples for simultaneous measurement of 92 proteins. Both HbA1c and FrAm inversely correlated with IL-10, FGF-21, MCP-1, and TNF beta amongst 16 proteins. HbA1c correlated directly with OPG. Parameters of disease severity were consistently significant for HbA1c. Adjusted PPD total and number of missing teeth were increased in diabetes whereas levels of RANKL and RANKL to OPG ratio were the highest in nondiabetic periodontitis patients. Hyperglycemic conditions in periodontitis patients are associated with reduced levels of anti-inflammatory proteins as well as dysregulated bone resorption. Hindawi 2020-01-10 /pmc/articles/PMC6977320/ /pubmed/31998807 http://dx.doi.org/10.1155/2020/6450742 Text en Copyright © 2020 Jeneen Panezai et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Panezai, Jeneen Altamash, Mohammad Engstrӧm, Per-Erik Larsson, Anders Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
title | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
title_full | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
title_fullStr | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
title_full_unstemmed | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
title_short | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
title_sort | association of glycated proteins with inflammatory proteins and periodontal disease parameters |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977320/ https://www.ncbi.nlm.nih.gov/pubmed/31998807 http://dx.doi.org/10.1155/2020/6450742 |
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