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MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes
INTRODUCTION: Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. A major challenge is to identify early diabetic nephropathy. microRNAs (miRNAs) are short noncoding RNA sequences and regulate a wide range of biological processes as cell differentiation, prolifera...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977383/ https://www.ncbi.nlm.nih.gov/pubmed/32015595 http://dx.doi.org/10.4103/ijn.IJN_80_19 |
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author | Fouad, Mohamed Salem, Ibrahim Elhefnawy, Khaled Raafat, Nermin Faisal, Amal |
author_facet | Fouad, Mohamed Salem, Ibrahim Elhefnawy, Khaled Raafat, Nermin Faisal, Amal |
author_sort | Fouad, Mohamed |
collection | PubMed |
description | INTRODUCTION: Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. A major challenge is to identify early diabetic nephropathy. microRNAs (miRNAs) are short noncoding RNA sequences and regulate a wide range of biological processes as cell differentiation, proliferation, cell metabolism and apoptosis. miRNAs may have a role in molecular mechanisms linked to cellular pathways of DN. The aim of this study was to investigate the level of microRNA-21 as a potential marker of early nephropathy in type 1 diabetes mellitus (T1DM). METHODS: A total number of 340 participants were included and classified into 3 groups; Group I included 100 healthy participants, Group II included 120 patients with T1DM with <5 years duration, and Group III included 120 patients with T1DM with >5 years duration. All participants were submitted to detail clinical examination, laboratory investigations, urinary albumin/creatinine ratio (ACR), estimated glomerular filtration rate (eGFR) as well as plasma microRNA-21 assays. RESULTS: Blood pressure and ACR were significantly higher in group III than groups I and II. Further, microRNA-21 was significantly higher in group III than groups I and II, and more in group II than group I. microRNA-21 starts to rise in group II before microalbuminuria. miRNA-21 at a level of 0.01 had a greater sensitivity 94.1% and specificity 100% for identifying DN than ACR at level 45 mg/gm with sensitivity 88.2% and specificity 89%. CONCLUSION: Plasma microRNA-21 can serve as an early marker for diagnosis and identifying diabetic nephropathy in T1DM. |
format | Online Article Text |
id | pubmed-6977383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-69773832020-02-03 MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes Fouad, Mohamed Salem, Ibrahim Elhefnawy, Khaled Raafat, Nermin Faisal, Amal Indian J Nephrol Original Article INTRODUCTION: Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. A major challenge is to identify early diabetic nephropathy. microRNAs (miRNAs) are short noncoding RNA sequences and regulate a wide range of biological processes as cell differentiation, proliferation, cell metabolism and apoptosis. miRNAs may have a role in molecular mechanisms linked to cellular pathways of DN. The aim of this study was to investigate the level of microRNA-21 as a potential marker of early nephropathy in type 1 diabetes mellitus (T1DM). METHODS: A total number of 340 participants were included and classified into 3 groups; Group I included 100 healthy participants, Group II included 120 patients with T1DM with <5 years duration, and Group III included 120 patients with T1DM with >5 years duration. All participants were submitted to detail clinical examination, laboratory investigations, urinary albumin/creatinine ratio (ACR), estimated glomerular filtration rate (eGFR) as well as plasma microRNA-21 assays. RESULTS: Blood pressure and ACR were significantly higher in group III than groups I and II. Further, microRNA-21 was significantly higher in group III than groups I and II, and more in group II than group I. microRNA-21 starts to rise in group II before microalbuminuria. miRNA-21 at a level of 0.01 had a greater sensitivity 94.1% and specificity 100% for identifying DN than ACR at level 45 mg/gm with sensitivity 88.2% and specificity 89%. CONCLUSION: Plasma microRNA-21 can serve as an early marker for diagnosis and identifying diabetic nephropathy in T1DM. Wolters Kluwer - Medknow 2020 2019-12-27 /pmc/articles/PMC6977383/ /pubmed/32015595 http://dx.doi.org/10.4103/ijn.IJN_80_19 Text en Copyright: © 2020 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Fouad, Mohamed Salem, Ibrahim Elhefnawy, Khaled Raafat, Nermin Faisal, Amal MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes |
title | MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes |
title_full | MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes |
title_fullStr | MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes |
title_full_unstemmed | MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes |
title_short | MicroRNA-21 as an Early Marker of Nephropathy in Patients with Type 1 Diabetes |
title_sort | microrna-21 as an early marker of nephropathy in patients with type 1 diabetes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977383/ https://www.ncbi.nlm.nih.gov/pubmed/32015595 http://dx.doi.org/10.4103/ijn.IJN_80_19 |
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