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Enantioselective synthesis of quaternary 3,4-dihydroisoquinolinones via Heck carbonylation reactions: development and application to the synthesis of Minalrestat analogues

Minalrestat and its analogues represent structurally novel aldose reductase inhibitors, and the asymmetric synthesis of such pharmaceutically privileged molecules has not been reported yet. We have developed a palladium-catalyzed enantioselective intramolecular carbonylative Heck reaction by using f...

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Detalles Bibliográficos
Autores principales:	Cheng, Cang, Wan, Bin, Zhou, Bo, Gu, Yichao, Zhang, Yanghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977551/ https://www.ncbi.nlm.nih.gov/pubmed/32015808 http://dx.doi.org/10.1039/c9sc03406d

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