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Therapeutic impacts of enzyme-responsive smart nanobiosystems

An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs...

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Detalles Bibliográficos
Autores principales: Fathi, Marziyeh, Safary, Azam, Barar, Jaleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977590/
https://www.ncbi.nlm.nih.gov/pubmed/31988850
http://dx.doi.org/10.15171/bi.2020.01
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author Fathi, Marziyeh
Safary, Azam
Barar, Jaleh
author_facet Fathi, Marziyeh
Safary, Azam
Barar, Jaleh
author_sort Fathi, Marziyeh
collection PubMed
description An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo molecules in the tumor microenvironment (TME) with a spatiotemporal controlled-release behavior. Based on the unique features of enzyme responsive/targeted DDSs, they offer incredible promise in overcoming some limitations of the currently used conventional DDSs. Taken all, targeting TME with the enzyme-responsive targeted DDSs may lead to versatile clinical outcomes in various malignancies.
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spelling pubmed-69775902020-01-27 Therapeutic impacts of enzyme-responsive smart nanobiosystems Fathi, Marziyeh Safary, Azam Barar, Jaleh Bioimpacts Editorial An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo molecules in the tumor microenvironment (TME) with a spatiotemporal controlled-release behavior. Based on the unique features of enzyme responsive/targeted DDSs, they offer incredible promise in overcoming some limitations of the currently used conventional DDSs. Taken all, targeting TME with the enzyme-responsive targeted DDSs may lead to versatile clinical outcomes in various malignancies. Tabriz University of Medical Sciences 2020 2019-11-25 /pmc/articles/PMC6977590/ /pubmed/31988850 http://dx.doi.org/10.15171/bi.2020.01 Text en © 2020 The Author(s) This work is published by BioImpacts as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Editorial
Fathi, Marziyeh
Safary, Azam
Barar, Jaleh
Therapeutic impacts of enzyme-responsive smart nanobiosystems
title Therapeutic impacts of enzyme-responsive smart nanobiosystems
title_full Therapeutic impacts of enzyme-responsive smart nanobiosystems
title_fullStr Therapeutic impacts of enzyme-responsive smart nanobiosystems
title_full_unstemmed Therapeutic impacts of enzyme-responsive smart nanobiosystems
title_short Therapeutic impacts of enzyme-responsive smart nanobiosystems
title_sort therapeutic impacts of enzyme-responsive smart nanobiosystems
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977590/
https://www.ncbi.nlm.nih.gov/pubmed/31988850
http://dx.doi.org/10.15171/bi.2020.01
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