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Therapeutic impacts of enzyme-responsive smart nanobiosystems
An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977590/ https://www.ncbi.nlm.nih.gov/pubmed/31988850 http://dx.doi.org/10.15171/bi.2020.01 |
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author | Fathi, Marziyeh Safary, Azam Barar, Jaleh |
author_facet | Fathi, Marziyeh Safary, Azam Barar, Jaleh |
author_sort | Fathi, Marziyeh |
collection | PubMed |
description | An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo molecules in the tumor microenvironment (TME) with a spatiotemporal controlled-release behavior. Based on the unique features of enzyme responsive/targeted DDSs, they offer incredible promise in overcoming some limitations of the currently used conventional DDSs. Taken all, targeting TME with the enzyme-responsive targeted DDSs may lead to versatile clinical outcomes in various malignancies. |
format | Online Article Text |
id | pubmed-6977590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-69775902020-01-27 Therapeutic impacts of enzyme-responsive smart nanobiosystems Fathi, Marziyeh Safary, Azam Barar, Jaleh Bioimpacts Editorial An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo molecules in the tumor microenvironment (TME) with a spatiotemporal controlled-release behavior. Based on the unique features of enzyme responsive/targeted DDSs, they offer incredible promise in overcoming some limitations of the currently used conventional DDSs. Taken all, targeting TME with the enzyme-responsive targeted DDSs may lead to versatile clinical outcomes in various malignancies. Tabriz University of Medical Sciences 2020 2019-11-25 /pmc/articles/PMC6977590/ /pubmed/31988850 http://dx.doi.org/10.15171/bi.2020.01 Text en © 2020 The Author(s) This work is published by BioImpacts as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Editorial Fathi, Marziyeh Safary, Azam Barar, Jaleh Therapeutic impacts of enzyme-responsive smart nanobiosystems |
title | Therapeutic impacts of enzyme-responsive smart nanobiosystems |
title_full | Therapeutic impacts of enzyme-responsive smart nanobiosystems |
title_fullStr | Therapeutic impacts of enzyme-responsive smart nanobiosystems |
title_full_unstemmed | Therapeutic impacts of enzyme-responsive smart nanobiosystems |
title_short | Therapeutic impacts of enzyme-responsive smart nanobiosystems |
title_sort | therapeutic impacts of enzyme-responsive smart nanobiosystems |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977590/ https://www.ncbi.nlm.nih.gov/pubmed/31988850 http://dx.doi.org/10.15171/bi.2020.01 |
work_keys_str_mv | AT fathimarziyeh therapeuticimpactsofenzymeresponsivesmartnanobiosystems AT safaryazam therapeuticimpactsofenzymeresponsivesmartnanobiosystems AT bararjaleh therapeuticimpactsofenzymeresponsivesmartnanobiosystems |