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Roles of Fibulin-2 in Carcinogenesis
Fibulin-2, an extracellular matrix (ECM) protein expressed in normal epithelia, is a kind of fibulin which is associated with basement membranes (BM) and elastic ECM fibers. The role of fibulin-2 has been recognized as an oncogene. The upregulation of fibulin-2 correlates with cancer development and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977632/ https://www.ncbi.nlm.nih.gov/pubmed/31915327 http://dx.doi.org/10.12659/MSM.918099 |
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author | Zhang, Huayue Hui, Dengcheng Fu, Xiaoling |
author_facet | Zhang, Huayue Hui, Dengcheng Fu, Xiaoling |
author_sort | Zhang, Huayue |
collection | PubMed |
description | Fibulin-2, an extracellular matrix (ECM) protein expressed in normal epithelia, is a kind of fibulin which is associated with basement membranes (BM) and elastic ECM fibers. The role of fibulin-2 has been recognized as an oncogene. The upregulation of fibulin-2 correlates with cancer development and progression. Furthermore, the upregulation of fibulin has been detected in ovarian cancer and stomach adenocarcinoma. However, the downregulation of fibulin has been detected in different intestinal and respiratory tumor cells. Additional studies have revealed that the role of fibulin-2 in carcinogenesis is context dependent and is caused by the interaction of fibulin proteins such as cell surface receptors and other ECM proteins, including integrins and syndecans. The present study summarizes the role of fibulin in carcinogenesis and its underlying molecular mechanism. |
format | Online Article Text |
id | pubmed-6977632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69776322020-02-03 Roles of Fibulin-2 in Carcinogenesis Zhang, Huayue Hui, Dengcheng Fu, Xiaoling Med Sci Monit Review Articles Fibulin-2, an extracellular matrix (ECM) protein expressed in normal epithelia, is a kind of fibulin which is associated with basement membranes (BM) and elastic ECM fibers. The role of fibulin-2 has been recognized as an oncogene. The upregulation of fibulin-2 correlates with cancer development and progression. Furthermore, the upregulation of fibulin has been detected in ovarian cancer and stomach adenocarcinoma. However, the downregulation of fibulin has been detected in different intestinal and respiratory tumor cells. Additional studies have revealed that the role of fibulin-2 in carcinogenesis is context dependent and is caused by the interaction of fibulin proteins such as cell surface receptors and other ECM proteins, including integrins and syndecans. The present study summarizes the role of fibulin in carcinogenesis and its underlying molecular mechanism. International Scientific Literature, Inc. 2020-01-09 /pmc/articles/PMC6977632/ /pubmed/31915327 http://dx.doi.org/10.12659/MSM.918099 Text en © Med Sci Monit, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Review Articles Zhang, Huayue Hui, Dengcheng Fu, Xiaoling Roles of Fibulin-2 in Carcinogenesis |
title | Roles of Fibulin-2 in Carcinogenesis |
title_full | Roles of Fibulin-2 in Carcinogenesis |
title_fullStr | Roles of Fibulin-2 in Carcinogenesis |
title_full_unstemmed | Roles of Fibulin-2 in Carcinogenesis |
title_short | Roles of Fibulin-2 in Carcinogenesis |
title_sort | roles of fibulin-2 in carcinogenesis |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977632/ https://www.ncbi.nlm.nih.gov/pubmed/31915327 http://dx.doi.org/10.12659/MSM.918099 |
work_keys_str_mv | AT zhanghuayue rolesoffibulin2incarcinogenesis AT huidengcheng rolesoffibulin2incarcinogenesis AT fuxiaoling rolesoffibulin2incarcinogenesis |