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Prognostic potential of PRPF3 in hepatocellular carcinoma

pre-mRNA processing factor 3 (PRPF3) is an RNA binding protein in a core component of the exon junction complex. Abnormal PRPF3 expression is potentially associated with carcinogenesis. However, the biological role of PRPF3 in hepatocellular carcinoma (HCC) remains to be determined. We analyzed PRPF...

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Autores principales: Liu, Yinlan, Yang, Yuhan, Luo, Yan, Wang, Juan, Lu, Xiangyun, Yang, Zongxing, Yang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977647/
https://www.ncbi.nlm.nih.gov/pubmed/31926109
http://dx.doi.org/10.18632/aging.102665
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author Liu, Yinlan
Yang, Yuhan
Luo, Yan
Wang, Juan
Lu, Xiangyun
Yang, Zongxing
Yang, Jin
author_facet Liu, Yinlan
Yang, Yuhan
Luo, Yan
Wang, Juan
Lu, Xiangyun
Yang, Zongxing
Yang, Jin
author_sort Liu, Yinlan
collection PubMed
description pre-mRNA processing factor 3 (PRPF3) is an RNA binding protein in a core component of the exon junction complex. Abnormal PRPF3 expression is potentially associated with carcinogenesis. However, the biological role of PRPF3 in hepatocellular carcinoma (HCC) remains to be determined. We analyzed PRPF3 expression via multiple gene expression databases and identified its genetic alterations and functional networks using cBioPortal. Co-expressed genes with PRPF3 and its regulators were identified using LinkedOmics. The correlations between PRPF3 and cancer immune infiltrates were investigated via Tumor Immune Estimation Resource (TIMER). PRPF3 was found up-regulated with amplification in tumor tissues in multiple HCC cohorts. High PRPF3 expression was associated with poorer overall survival (OS) and disease-free survival (DFS). Functional network analysis suggested that PRPF3 regulates spliceosome, DNA replication, and cell cycle signaling via pathways involving several cancer-related kinases and E2F family. Notably, PRPF3 expression was positively correlated with infiltrating levels of CD4+ T and CD8+ T cells, macrophages, neutrophils, and dendritic cells. PRPF3 expression showed strong correlations with diverse immune marker sets in HCC. These findings suggest that PRPF3 is correlated with prognosis and immune infiltrating in HCC, laying a foundation for further study of the immune regulatory role of PRPF3 in HCC.
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spelling pubmed-69776472020-01-31 Prognostic potential of PRPF3 in hepatocellular carcinoma Liu, Yinlan Yang, Yuhan Luo, Yan Wang, Juan Lu, Xiangyun Yang, Zongxing Yang, Jin Aging (Albany NY) Research Paper pre-mRNA processing factor 3 (PRPF3) is an RNA binding protein in a core component of the exon junction complex. Abnormal PRPF3 expression is potentially associated with carcinogenesis. However, the biological role of PRPF3 in hepatocellular carcinoma (HCC) remains to be determined. We analyzed PRPF3 expression via multiple gene expression databases and identified its genetic alterations and functional networks using cBioPortal. Co-expressed genes with PRPF3 and its regulators were identified using LinkedOmics. The correlations between PRPF3 and cancer immune infiltrates were investigated via Tumor Immune Estimation Resource (TIMER). PRPF3 was found up-regulated with amplification in tumor tissues in multiple HCC cohorts. High PRPF3 expression was associated with poorer overall survival (OS) and disease-free survival (DFS). Functional network analysis suggested that PRPF3 regulates spliceosome, DNA replication, and cell cycle signaling via pathways involving several cancer-related kinases and E2F family. Notably, PRPF3 expression was positively correlated with infiltrating levels of CD4+ T and CD8+ T cells, macrophages, neutrophils, and dendritic cells. PRPF3 expression showed strong correlations with diverse immune marker sets in HCC. These findings suggest that PRPF3 is correlated with prognosis and immune infiltrating in HCC, laying a foundation for further study of the immune regulatory role of PRPF3 in HCC. Impact Journals 2020-01-11 /pmc/articles/PMC6977647/ /pubmed/31926109 http://dx.doi.org/10.18632/aging.102665 Text en Copyright © 2020 Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liu, Yinlan
Yang, Yuhan
Luo, Yan
Wang, Juan
Lu, Xiangyun
Yang, Zongxing
Yang, Jin
Prognostic potential of PRPF3 in hepatocellular carcinoma
title Prognostic potential of PRPF3 in hepatocellular carcinoma
title_full Prognostic potential of PRPF3 in hepatocellular carcinoma
title_fullStr Prognostic potential of PRPF3 in hepatocellular carcinoma
title_full_unstemmed Prognostic potential of PRPF3 in hepatocellular carcinoma
title_short Prognostic potential of PRPF3 in hepatocellular carcinoma
title_sort prognostic potential of prpf3 in hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977647/
https://www.ncbi.nlm.nih.gov/pubmed/31926109
http://dx.doi.org/10.18632/aging.102665
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