Cargando…

Association of adult lung function with accelerated biological aging

Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their r...

Descripción completa

Detalles Bibliográficos
Autores principales: Rezwan, Faisal I., Imboden, Medea, Amaral, Andre F.S., Wielscher, Matthias, Jeong, Ayoung, Triebner, Kai, Real, Francisco Gómez, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Probst-Hensch, Nicole M., Holloway, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977706/
https://www.ncbi.nlm.nih.gov/pubmed/31926111
http://dx.doi.org/10.18632/aging.102639
_version_ 1783490569760145408
author Rezwan, Faisal I.
Imboden, Medea
Amaral, Andre F.S.
Wielscher, Matthias
Jeong, Ayoung
Triebner, Kai
Real, Francisco Gómez
Jarvelin, Marjo-Riitta
Jarvis, Deborah
Probst-Hensch, Nicole M.
Holloway, John W.
author_facet Rezwan, Faisal I.
Imboden, Medea
Amaral, Andre F.S.
Wielscher, Matthias
Jeong, Ayoung
Triebner, Kai
Real, Francisco Gómez
Jarvelin, Marjo-Riitta
Jarvis, Deborah
Probst-Hensch, Nicole M.
Holloway, John W.
author_sort Rezwan, Faisal I.
collection PubMed
description Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed. AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10(-4); Intrinsic Epigenetic AA:P-value=2x10(-4)) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10(-17)). This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.
format Online
Article
Text
id pubmed-6977706
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Impact Journals
record_format MEDLINE/PubMed
spelling pubmed-69777062020-01-31 Association of adult lung function with accelerated biological aging Rezwan, Faisal I. Imboden, Medea Amaral, Andre F.S. Wielscher, Matthias Jeong, Ayoung Triebner, Kai Real, Francisco Gómez Jarvelin, Marjo-Riitta Jarvis, Deborah Probst-Hensch, Nicole M. Holloway, John W. Aging (Albany NY) Research Paper Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed. AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10(-4); Intrinsic Epigenetic AA:P-value=2x10(-4)) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10(-17)). This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults. Impact Journals 2020-01-11 /pmc/articles/PMC6977706/ /pubmed/31926111 http://dx.doi.org/10.18632/aging.102639 Text en Copyright © 2020 Rezwan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Rezwan, Faisal I.
Imboden, Medea
Amaral, Andre F.S.
Wielscher, Matthias
Jeong, Ayoung
Triebner, Kai
Real, Francisco Gómez
Jarvelin, Marjo-Riitta
Jarvis, Deborah
Probst-Hensch, Nicole M.
Holloway, John W.
Association of adult lung function with accelerated biological aging
title Association of adult lung function with accelerated biological aging
title_full Association of adult lung function with accelerated biological aging
title_fullStr Association of adult lung function with accelerated biological aging
title_full_unstemmed Association of adult lung function with accelerated biological aging
title_short Association of adult lung function with accelerated biological aging
title_sort association of adult lung function with accelerated biological aging
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977706/
https://www.ncbi.nlm.nih.gov/pubmed/31926111
http://dx.doi.org/10.18632/aging.102639
work_keys_str_mv AT rezwanfaisali associationofadultlungfunctionwithacceleratedbiologicalaging
AT imbodenmedea associationofadultlungfunctionwithacceleratedbiologicalaging
AT amaralandrefs associationofadultlungfunctionwithacceleratedbiologicalaging
AT wielschermatthias associationofadultlungfunctionwithacceleratedbiologicalaging
AT jeongayoung associationofadultlungfunctionwithacceleratedbiologicalaging
AT triebnerkai associationofadultlungfunctionwithacceleratedbiologicalaging
AT realfranciscogomez associationofadultlungfunctionwithacceleratedbiologicalaging
AT jarvelinmarjoriitta associationofadultlungfunctionwithacceleratedbiologicalaging
AT jarvisdeborah associationofadultlungfunctionwithacceleratedbiologicalaging
AT probsthenschnicolem associationofadultlungfunctionwithacceleratedbiologicalaging
AT hollowayjohnw associationofadultlungfunctionwithacceleratedbiologicalaging