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Association of adult lung function with accelerated biological aging
Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their r...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977706/ https://www.ncbi.nlm.nih.gov/pubmed/31926111 http://dx.doi.org/10.18632/aging.102639 |
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author | Rezwan, Faisal I. Imboden, Medea Amaral, Andre F.S. Wielscher, Matthias Jeong, Ayoung Triebner, Kai Real, Francisco Gómez Jarvelin, Marjo-Riitta Jarvis, Deborah Probst-Hensch, Nicole M. Holloway, John W. |
author_facet | Rezwan, Faisal I. Imboden, Medea Amaral, Andre F.S. Wielscher, Matthias Jeong, Ayoung Triebner, Kai Real, Francisco Gómez Jarvelin, Marjo-Riitta Jarvis, Deborah Probst-Hensch, Nicole M. Holloway, John W. |
author_sort | Rezwan, Faisal I. |
collection | PubMed |
description | Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed. AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10(-4); Intrinsic Epigenetic AA:P-value=2x10(-4)) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10(-17)). This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults. |
format | Online Article Text |
id | pubmed-6977706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-69777062020-01-31 Association of adult lung function with accelerated biological aging Rezwan, Faisal I. Imboden, Medea Amaral, Andre F.S. Wielscher, Matthias Jeong, Ayoung Triebner, Kai Real, Francisco Gómez Jarvelin, Marjo-Riitta Jarvis, Deborah Probst-Hensch, Nicole M. Holloway, John W. Aging (Albany NY) Research Paper Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed. AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10(-4); Intrinsic Epigenetic AA:P-value=2x10(-4)) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10(-17)). This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults. Impact Journals 2020-01-11 /pmc/articles/PMC6977706/ /pubmed/31926111 http://dx.doi.org/10.18632/aging.102639 Text en Copyright © 2020 Rezwan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Rezwan, Faisal I. Imboden, Medea Amaral, Andre F.S. Wielscher, Matthias Jeong, Ayoung Triebner, Kai Real, Francisco Gómez Jarvelin, Marjo-Riitta Jarvis, Deborah Probst-Hensch, Nicole M. Holloway, John W. Association of adult lung function with accelerated biological aging |
title | Association of adult lung function with accelerated biological aging |
title_full | Association of adult lung function with accelerated biological aging |
title_fullStr | Association of adult lung function with accelerated biological aging |
title_full_unstemmed | Association of adult lung function with accelerated biological aging |
title_short | Association of adult lung function with accelerated biological aging |
title_sort | association of adult lung function with accelerated biological aging |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977706/ https://www.ncbi.nlm.nih.gov/pubmed/31926111 http://dx.doi.org/10.18632/aging.102639 |
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