Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review

We conducted a systematic review and a fixed-effects meta-analysis to determine whether incident adverse psychiatric events (APE) including depression, anxiety, psychosis, or suicide were associated with biologic therapy in IBD. Six randomized controlled trials and a cohort study met criteria, repor...

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Autores principales: Jain, Avni, Marrie, Ruth Ann, Shafer, Leigh Anne, Graff, Lesley A, Patten, Scott B, El-Gabalawy, Renée, Sareen, Jitender, Bolton, James M, Fisk, John D, Bernstein, Charles N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977711/
https://www.ncbi.nlm.nih.gov/pubmed/32003760
http://dx.doi.org/10.1093/crocol/otz053
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author Jain, Avni
Marrie, Ruth Ann
Shafer, Leigh Anne
Graff, Lesley A
Patten, Scott B
El-Gabalawy, Renée
Sareen, Jitender
Bolton, James M
Fisk, John D
Bernstein, Charles N
author_facet Jain, Avni
Marrie, Ruth Ann
Shafer, Leigh Anne
Graff, Lesley A
Patten, Scott B
El-Gabalawy, Renée
Sareen, Jitender
Bolton, James M
Fisk, John D
Bernstein, Charles N
author_sort Jain, Avni
collection PubMed
description We conducted a systematic review and a fixed-effects meta-analysis to determine whether incident adverse psychiatric events (APE) including depression, anxiety, psychosis, or suicide were associated with biologic therapy in IBD. Six randomized controlled trials and a cohort study met criteria, reporting an incidence of APE in 4,882 patients. The risk difference per 100 person-months of any APE with a biologic medication was 0.01 (95% confidence interval = 0.00–0.02). There was insufficient evidence available in randomized controlled trials to conclude that biologic therapy in IBD is associated with an increased incidence of APE.
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spelling pubmed-69777112020-01-28 Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review Jain, Avni Marrie, Ruth Ann Shafer, Leigh Anne Graff, Lesley A Patten, Scott B El-Gabalawy, Renée Sareen, Jitender Bolton, James M Fisk, John D Bernstein, Charles N Crohns Colitis 360 Observations and Research We conducted a systematic review and a fixed-effects meta-analysis to determine whether incident adverse psychiatric events (APE) including depression, anxiety, psychosis, or suicide were associated with biologic therapy in IBD. Six randomized controlled trials and a cohort study met criteria, reporting an incidence of APE in 4,882 patients. The risk difference per 100 person-months of any APE with a biologic medication was 0.01 (95% confidence interval = 0.00–0.02). There was insufficient evidence available in randomized controlled trials to conclude that biologic therapy in IBD is associated with an increased incidence of APE. Oxford University Press 2019-12-19 /pmc/articles/PMC6977711/ /pubmed/32003760 http://dx.doi.org/10.1093/crocol/otz053 Text en © 2019 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Observations and Research
Jain, Avni
Marrie, Ruth Ann
Shafer, Leigh Anne
Graff, Lesley A
Patten, Scott B
El-Gabalawy, Renée
Sareen, Jitender
Bolton, James M
Fisk, John D
Bernstein, Charles N
Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review
title Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review
title_full Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review
title_fullStr Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review
title_full_unstemmed Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review
title_short Incidence of Adverse Psychiatric Events During Treatment of Inflammatory Bowel Disease With Biologic Therapies: A Systematic Review
title_sort incidence of adverse psychiatric events during treatment of inflammatory bowel disease with biologic therapies: a systematic review
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977711/
https://www.ncbi.nlm.nih.gov/pubmed/32003760
http://dx.doi.org/10.1093/crocol/otz053
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