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Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing
SWC files are a widely used format to store neuron morphologies, and are used to share digitally reconstructed neurons using NeuroMorpho.org as well as predict functional attributes using simulation environments such as NEURON. Here we set out to develop an easily accessible tool to validate and cor...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977721/ https://www.ncbi.nlm.nih.gov/pubmed/31971963 http://dx.doi.org/10.1371/journal.pone.0228091 |
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author | O’Halloran, Damien M. |
author_facet | O’Halloran, Damien M. |
author_sort | O’Halloran, Damien M. |
collection | PubMed |
description | SWC files are a widely used format to store neuron morphologies, and are used to share digitally reconstructed neurons using NeuroMorpho.org as well as predict functional attributes using simulation environments such as NEURON. Here we set out to develop an easily accessible tool to validate and correct SWC formatted files with an emphasis on high throughput batch processing. SWC_BATCH_CHECK is a package that provides a suite of methods to parse and correct the syntactic structure of a directory of SWC files. This tool ensures that user specified structures such as the soma or basal dendrite are correctly connected while fixing morphological features. This tool will report on missing or invalid data values while also returning basic statistical features for each file. SWC_BATCH_CHECK was validated and tested using thousands of individual SWC files to benchmark runtime performance and efficacy in both reporting on and correcting disparate SWC file features. SWC_BATCH_CHECK is open source and freely available to all users without restriction with guidelines and requirements provided to ensure straightforward installation and execution. |
format | Online Article Text |
id | pubmed-6977721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69777212020-02-07 Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing O’Halloran, Damien M. PLoS One Research Article SWC files are a widely used format to store neuron morphologies, and are used to share digitally reconstructed neurons using NeuroMorpho.org as well as predict functional attributes using simulation environments such as NEURON. Here we set out to develop an easily accessible tool to validate and correct SWC formatted files with an emphasis on high throughput batch processing. SWC_BATCH_CHECK is a package that provides a suite of methods to parse and correct the syntactic structure of a directory of SWC files. This tool ensures that user specified structures such as the soma or basal dendrite are correctly connected while fixing morphological features. This tool will report on missing or invalid data values while also returning basic statistical features for each file. SWC_BATCH_CHECK was validated and tested using thousands of individual SWC files to benchmark runtime performance and efficacy in both reporting on and correcting disparate SWC file features. SWC_BATCH_CHECK is open source and freely available to all users without restriction with guidelines and requirements provided to ensure straightforward installation and execution. Public Library of Science 2020-01-23 /pmc/articles/PMC6977721/ /pubmed/31971963 http://dx.doi.org/10.1371/journal.pone.0228091 Text en © 2020 Damien M. O’Halloran http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article O’Halloran, Damien M. Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing |
title | Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing |
title_full | Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing |
title_fullStr | Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing |
title_full_unstemmed | Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing |
title_short | Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing |
title_sort | module for swc neuron morphology file validation and correction enabled for high throughput batch processing |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977721/ https://www.ncbi.nlm.nih.gov/pubmed/31971963 http://dx.doi.org/10.1371/journal.pone.0228091 |
work_keys_str_mv | AT ohallorandamienm moduleforswcneuronmorphologyfilevalidationandcorrectionenabledforhighthroughputbatchprocessing |