Synthesis and validation of [(18)F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone

BACKGROUND: Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell growth and proliferation pathways it is now targeted in combination treatments...

Descripción completa

Detalles Bibliográficos
Autores principales: Wichmann, Christian W., Goh, Yit Wooi, Parslow, Adam C., Rigopoulos, Angela, Guo, Nancy, Scott, Andrew M., Ackermann, Uwe, White, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977806/
https://www.ncbi.nlm.nih.gov/pubmed/31974638
http://dx.doi.org/10.1186/s41181-020-0089-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977806/
https://www.ncbi.nlm.nih.gov/pubmed/31974638
http://dx.doi.org/10.1186/s41181-020-0089-9

Ejemplares similares