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Synthesis and validation of [(18)F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone
BACKGROUND: Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell growth and proliferation pathways it is now targeted in combination treatments...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977806/ https://www.ncbi.nlm.nih.gov/pubmed/31974638 http://dx.doi.org/10.1186/s41181-020-0089-9 |