Cargando…
Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts
Interleukin (IL)−13 is a type 2 cytokine with important roles in allergic diseases, asthma, and tissue fibrosis. Its receptor (R) α1 is primarily responsible for the biological actions of this cytokine, while Rα2 possesses a decoy function which can block IL-13 signaling. Although the expression of...
Autores principales: | Penke, Loka R., Ouchi, Hideyasu, Speth, Jennifer M., Lugogo, Njira, Huang, Yvonne J., Huang, Steven K., Peters-Golden, Marc |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978327/ https://www.ncbi.nlm.nih.gov/pubmed/31974428 http://dx.doi.org/10.1038/s41598-020-57972-1 |
Ejemplares similares
-
KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis
por: Penke, Loka R., et al.
Publicado: (2022) -
2165 Vesicular secretion of suppressor of cytokine signaling 3 by alveolar macrophages is dysregulated in NSCLC patients and its provision inhibits epithelial cell transformation and tumor cell function
por: Speth, Jennifer, et al.
Publicado: (2018) -
PGE(2) accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
por: Penke, Loka R, et al.
Publicado: (2020) -
Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions
por: Fortier, Sean M., et al.
Publicado: (2021) -
Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex
por: Tollenaere, Maxim A.X., et al.
Publicado: (2023)