Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

Dysfunction of invariant natural killer T (iNKT) cells in tumor microenvironment hinders their anti-tumor efficacy, and the underlying mechanisms remain unclear. Here we report that iNKT cells increase lipid biosynthesis after activation, and that is promoted by PPARγ and PLZF synergically through e...

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Detalles Bibliográficos
Autores principales: Fu, Sicheng, He, Kaixin, Tian, Chenxi, Sun, Hua, Zhu, Chenwen, Bai, Shiyu, Liu, Jiwei, Wu, Qielan, Xie, Di, Yue, Ting, Shen, Zhuxia, Dai, Qingqing, Yu, Xiaojun, Zhu, Shu, Liu, Gang, Zhou, Rongbin, Duan, Shengzhong, Tian, Zhigang, Xu, Tao, Wang, Hua, Bai, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978340/
https://www.ncbi.nlm.nih.gov/pubmed/31974378
http://dx.doi.org/10.1038/s41467-020-14332-x

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