Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Immune checkpoint inhibitors (ICIs) have dramatically modified the prognosis of several advanced cancers, however many patients still do not respond to treatment. Optimal results might be obtained by targeting cancer cell metabolism to modulate the immunosuppressive tumor microenvironment. Here, we...

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Detalles Bibliográficos
Autores principales: Imbert, Caroline, Montfort, Anne, Fraisse, Marine, Marcheteau, Elie, Gilhodes, Julia, Martin, Elodie, Bertrand, Florie, Marcellin, Marlène, Burlet-Schiltz, Odile, Peredo, Anne Gonzalez de, Garcia, Virginie, Carpentier, Stéphane, Tartare-Deckert, Sophie, Brousset, Pierre, Rochaix, Philippe, Puisset, Florent, Filleron, Thomas, Meyer, Nicolas, Lamant, Laurence, Levade, Thierry, Ségui, Bruno, Andrieu-Abadie, Nathalie, Colacios, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978345/
https://www.ncbi.nlm.nih.gov/pubmed/31974367
http://dx.doi.org/10.1038/s41467-019-14218-7

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