Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that govern PB1 domain filament formation in vitro remain to be determined and the role of p62 filaments inside the ce...

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Detalles Bibliográficos
Autores principales: Jakobi, Arjen J., Huber, Stefan T., Mortensen, Simon A., Schultz, Sebastian W., Palara, Anthimi, Kuhm, Tanja, Shrestha, Birendra Kumar, Lamark, Trond, Hagen, Wim J. H., Wilmanns, Matthias, Johansen, Terje, Brech, Andreas, Sachse, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978347/
https://www.ncbi.nlm.nih.gov/pubmed/31974402
http://dx.doi.org/10.1038/s41467-020-14343-8

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