Cargando…
Unique IL-13Rα2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination
This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated IL-13 responses at the lung mucosae, unlike...
Autores principales: | Roy, Sreeja, Liu, Ho-Ying, Jaeson, Muhammad Irwan, Deimel, Lachlan Paul, Ranasinghe, Charani |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978450/ https://www.ncbi.nlm.nih.gov/pubmed/31974500 http://dx.doi.org/10.1038/s41598-020-57815-z |
Ejemplares similares
-
IL-13Rα2 Regulates the IL-13/IFN-γ Balance during Innate Lymphoid Cell and Dendritic Cell Responses to Pox Viral Vector-Based Vaccination
por: Li, Zheyi, et al.
Publicado: (2021) -
STAT3 determines IL-4 signalling outcomes in naïve T cells
por: Deimel, Lachlan P., et al.
Publicado: (2021) -
Interleukin-13 as a target to alleviate severe coronavirus disease 2019 and restore lung homeostasis
por: Deimel, Lachlan Paul, et al.
Publicado: (2021) -
Vaccination route can significantly alter the innate lymphoid cell subsets: a feedback between IL-13 and IFN-γ
por: Li, Zheyi, et al.
Publicado: (2018) -
A unique role for IL-13 in inducing esophageal eosinophilia through MID-1 and STAT6
por: Girkin, Jason L. N., et al.
Publicado: (2023)