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Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes
Pifithrin-α (PFT-α) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity. However, its molecular mechanism of action remains unclear. PFT-α has also been described to display potent p53-independent activity in cells. In this study, we addressed the mec...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978515/ https://www.ncbi.nlm.nih.gov/pubmed/31974452 http://dx.doi.org/10.1038/s41598-020-58051-1 |