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TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

Acidosis, a common characteristic of the tumor microenvironment, is associated with alterations in metabolic preferences of cancer cells and progression of the disease. Here we identify the TGF-β2 isoform at the interface between these observations. We document that acidic pH promotes autocrine TGF-...

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Detalles Bibliográficos
Autores principales:	Corbet, Cyril, Bastien, Estelle, Santiago de Jesus, Joao Pedro, Dierge, Emeline, Martherus, Ruben, Vander Linden, Catherine, Doix, Bastien, Degavre, Charline, Guilbaud, Céline, Petit, Laurenne, Michiels, Carine, Dessy, Chantal, Larondelle, Yvan, Feron, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978517/ https://www.ncbi.nlm.nih.gov/pubmed/31974393 http://dx.doi.org/10.1038/s41467-019-14262-3

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