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Interleukin-6 in pregnancy with sickle cell disease

BACKGROUND: Despite advances in health care for sickle cell disease patients, as well as in the improvement in reproductive issues mainly in women with the disease, pregnancy is still a challenge, both for the mother and the child, with high rates of maternal and fetal morbidity and mortality. Besid...

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Autores principales: Costa, Manuela Freire Hazin, Torres, Leuridan Cavalcante, Matta, Marina Cadena da, Araújo, Aderson da Silva, Souza, Ariani Impieri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Hematologia e Hemoterapia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978540/
https://www.ncbi.nlm.nih.gov/pubmed/31133499
http://dx.doi.org/10.1016/j.htct.2019.02.001
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author Costa, Manuela Freire Hazin
Torres, Leuridan Cavalcante
Matta, Marina Cadena da
Araújo, Aderson da Silva
Souza, Ariani Impieri
author_facet Costa, Manuela Freire Hazin
Torres, Leuridan Cavalcante
Matta, Marina Cadena da
Araújo, Aderson da Silva
Souza, Ariani Impieri
author_sort Costa, Manuela Freire Hazin
collection PubMed
description BACKGROUND: Despite advances in health care for sickle cell disease patients, as well as in the improvement in reproductive issues mainly in women with the disease, pregnancy is still a challenge, both for the mother and the child, with high rates of maternal and fetal morbidity and mortality. Besides their chronic hemolytic status and vaso-occlusive events that confer systemic complications, pregnant women also have higher rates of pain episodes, infections, abortion, intrauterine growth retardation, pre-term births, eclampsia, stillbirth and the hemolysis, elevated liver enzymes and low platelets syndrome. The physiologic mechanisms of the disease in pregnancy are still unknown and chronic inflammatory responses may interfere in the adverse outcomes. The cytokine and chemokine profiles in pregnancy with sickle cell disease remain unknown. The aim of this study was to evaluate the cytokine profile of the inflammatory response of pregnant women with sickle cell disease. METHOD: Blood samples from 20 pregnant women with sickle cell disease, 24 women with sickle cell disease in steady state, 16 healthy pregnant women and a control group with 9 women at childbearing age were assayed for interleukin-6. MAIN RESULTS: Pregnant women with sickle cell disease presented high serum levels of interleukin-6, compared to healthy pregnant women (p = 0.0115). CONCLUSION: These data suggest that the increased production of interleukin-6 may occur during pregnancy with sickle cell disease and that the role of this cytokine in the sickle cell disease pathophysiology and pregnancy complications should be further studied.
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spelling pubmed-69785402020-01-28 Interleukin-6 in pregnancy with sickle cell disease Costa, Manuela Freire Hazin Torres, Leuridan Cavalcante Matta, Marina Cadena da Araújo, Aderson da Silva Souza, Ariani Impieri Hematol Transfus Cell Ther Original Article BACKGROUND: Despite advances in health care for sickle cell disease patients, as well as in the improvement in reproductive issues mainly in women with the disease, pregnancy is still a challenge, both for the mother and the child, with high rates of maternal and fetal morbidity and mortality. Besides their chronic hemolytic status and vaso-occlusive events that confer systemic complications, pregnant women also have higher rates of pain episodes, infections, abortion, intrauterine growth retardation, pre-term births, eclampsia, stillbirth and the hemolysis, elevated liver enzymes and low platelets syndrome. The physiologic mechanisms of the disease in pregnancy are still unknown and chronic inflammatory responses may interfere in the adverse outcomes. The cytokine and chemokine profiles in pregnancy with sickle cell disease remain unknown. The aim of this study was to evaluate the cytokine profile of the inflammatory response of pregnant women with sickle cell disease. METHOD: Blood samples from 20 pregnant women with sickle cell disease, 24 women with sickle cell disease in steady state, 16 healthy pregnant women and a control group with 9 women at childbearing age were assayed for interleukin-6. MAIN RESULTS: Pregnant women with sickle cell disease presented high serum levels of interleukin-6, compared to healthy pregnant women (p = 0.0115). CONCLUSION: These data suggest that the increased production of interleukin-6 may occur during pregnancy with sickle cell disease and that the role of this cytokine in the sickle cell disease pathophysiology and pregnancy complications should be further studied. Sociedade Brasileira de Hematologia e Hemoterapia 2019 2019-05-11 /pmc/articles/PMC6978540/ /pubmed/31133499 http://dx.doi.org/10.1016/j.htct.2019.02.001 Text en © 2019 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Costa, Manuela Freire Hazin
Torres, Leuridan Cavalcante
Matta, Marina Cadena da
Araújo, Aderson da Silva
Souza, Ariani Impieri
Interleukin-6 in pregnancy with sickle cell disease
title Interleukin-6 in pregnancy with sickle cell disease
title_full Interleukin-6 in pregnancy with sickle cell disease
title_fullStr Interleukin-6 in pregnancy with sickle cell disease
title_full_unstemmed Interleukin-6 in pregnancy with sickle cell disease
title_short Interleukin-6 in pregnancy with sickle cell disease
title_sort interleukin-6 in pregnancy with sickle cell disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978540/
https://www.ncbi.nlm.nih.gov/pubmed/31133499
http://dx.doi.org/10.1016/j.htct.2019.02.001
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